New York, NY (March 21, 2019)--Delusions are one of the most common symptoms of psychosis, but little is known about what causes them. A new study from researchers at Columbia University and New York State Psychiatric Institute offers insight into the development of delusions, which could lead to better treatments for people with psychosis.
The findings were published in Brain.
An estimated 80-90 percent of individuals with schizophrenia and other psychotic disorders experience delusions -- false, but strongly held, beliefs that can be distressing and debilitating. Researchers have long suspected that delusions are caused by alterations in the ability to make inferences, which relies on observable evidence to shape beliefs. However, previous experiments have suggested that other cognitive processes may be involved.
"The experiments typically used to understand the link between inference and delusions have focused on cognitive and decision-making skills, but they haven't conclusively shown a link between inference-making and delusion severity," says Guillermo Horga, MD, PhD, the Florence Irving Assistant Professor of Psychiatry at Columbia University Vagelos College of Physicians and Surgeons and lead author of the paper. "We developed a novel experiment to determine whether delusions stem from abnormalities in inference."
In the experiment, Horga and his team asked 26 adults with schizophrenia, including 12 who were being treated with antipsychotic medications, and 25 healthy individuals to draw beads from one of two hidden jars. Participants were given money, which could be used to bet on the identity of the hidden jar. They were told that drawing additional beads would help them bet correctly, though it would diminish their winnings. Throughout the experiment, they were asked to rate the odds of their bet on the identity of the jar.
"We found that patients who experienced more severe delusions tended to seek more information in the task before making a guess than their less-delusional counterparts. This is a truly novel finding, and it helps confirm the fact that rigidity is an important part of delusional beliefs," says Horga.
Using computational modeling, the researchers developed a quantitative framework casting delusions as "sticky" beliefs that evolve in an unusually slow way. This may explain why delusional patients seek more information than non-delusional individuals. It could also help to identify new treatment approaches, such as neurostimulation of the prefrontal brain areas involved in updating beliefs, or cognitive training to shape inference-making.
"Previous work suggested that psychotic patients 'jump to conclusions,' but in our study we saw that individuals with more delusional beliefs took more beads from the jar before they made up their minds," Horga continues. "While participants with schizophrenia jumped to conclusions more than healthy individuals, delusions specifically were associated with slower change in individuals' beliefs."
Jeffrey Lieberman, MD, Lawrence C. Kolb Professor and Chairman of Psychiatry at Columbia University Vagelos College of Physicians and Surgeons, commented that "delusions are among the most common and intractable symptoms of psychotic disorders. This innovative research casts delusions in a new context which allows for novel cognitive therapeutic approaches aimed at preventing and disrupting delusional thoughts."
The study is titled, "A distinct inferential mechanism for delusions in schizophrenia."
The other authors are Seth C. Baker, B.A, M.S. (Columbia University Irving Medical Center), Anna B. Konova, Ph.D (Rutgers University), and Nathanial D. Daw, Ph.D (Princeton University).
The study was supported by grant K23-MH101637 (PI: GH) as well as a pilot grant awarded by the Sydney R. Baer Jr. Foundation (PI: GH).
The authors report no financial or other conflicts of interest.
Columbia University Department of Psychiatry
Columbia Psychiatry is among the top ranked psychiatry departments in the nation and has contributed greatly to the understanding and treatment of brain disorders. Co-located at the New York State Psychiatric Institute on the NewYork-Presbyterian Hospital/Columbia University Irving Medical Center campus in Washington Heights, the department enjoys a rich and productive collaborative relationship with physicians in various disciplines at the Columbia University Vagelos College of Physicians and Surgeons. Columbia Psychiatry is home to distinguished clinicians and researchers noted for their clinical and research advances in the diagnosis and treatment of depression, suicide, schizophrenia, bipolar and anxiety disorders, eating disorders, substance use disorders, and childhood psychiatric disorders.
Columbia University Department of Psychiatry/New York State Psychiatric Institute
New York State Psychiatric Institute was founded in 1896 and has been closely affiliated with the Columbia University Department of Psychiatry since 1925. NYSPI/Columbia Psychiatry is ranked among the best departments and psychiatric research facilities in the nation and has contributed greatly to the understanding of and current treatment for psychiatric disorders. It is home to distinguished clinicians and researchers noted for their clinical and research advances in the diagnosis and treatment of depression, suicide, schizophrenia, bipolar and anxiety disorders and childhood psychiatric disorders. Their combined expertise provides state of the art clinical care for patients, and training for the next generation of psychiatrists and psychiatric researchers.
Columbia University Irving Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the Vagelos College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Irving Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. For more information, visit cumc.columbia.edu or columbiadoctors.org.