image: Synthetic polymers, such as the one represented above that codes for "ACS," can store data and be used to thwart counterfeiters. view more
Credit: Jean-François Lutz
ORLANDO, Fla., April 1, 2019 -- Drawing inspiration from nature, researchers are making polymers with ever-more precise compositions on demand. Using multistep synthesis tools pulled from biology, biochemistry and organic synthesis, a group is reporting that it is developing ultra-high precision synthetic polymers with precisely controlled chain lengths and monomer sequences. The resulting information-containing macromolecules can be deployed for data storage, anti-counterfeiting and traceability technologies.
The researchers will present their results today at the American Chemical Society (ACS) Spring 2019 National Meeting & Exposition. ACS, the world's largest scientific society, is holding the meeting here through Thursday. It features nearly 13,000 presentations on a wide range of science topics.
"There are basically two types of polymers," says Jean-François Lutz, Ph.D. "One type is plastic, which is made by humans. The other type is called a biopolymer, and it is a much more defined molecule. In fact, humans are mostly constructed with polymers -- DNA and proteins."
Conventional chemistry fabrication techniques can produce polymers of irregular lengths and sequences. But, Lutz notes, nature is more precise. There is a huge difference in structural quality between manmade and biological polymers, he explains. "The purpose of our work is to fill in the gap -- to make synthetic polymers using biological inspiration."
Generally, sequence-controlled polymers can be constructed either by chain-growth or step-growth polymerizations. Both approaches can achieve polymer chains of different lengths. However, when different monomers are combined into polymers, they will vary in chain-to-chain composition and sequence. Such polymers are not ideal for applications, such as coding, in which a precise, uniform structure is needed.
Lutz and his group at the Institut Charles Sadron have been working on building synthetic molecules with the same precision and uniformity as biological macromolecules. "We got the initial inspiration from DNA, which is a polymer made with four monomers: adenine, thymine, guanine and cytosine," Lutz says. "Although DNA is a polymer that codes for the very information that makes us human -- an important achievement -- it is really not the best structure for many other things. We thought that maybe we could make a polymer that is just as information-rich, but enhance the structure so it could be used for a variety of applications."
The group constructs its synthetic polymers with fully controlled primary structures using solid-phase iterative chemistry, a process that was originally developed to make peptides, or short bits of proteins. In the last few years, the team has been making precisely tailored polymers for data-storage applications. In these polymers, each monomer or subunit stands for a specific piece of information. So far, the researchers have created tiny data storage devices made of layered sequence-coded polymers. Recently, they also have studied the crystallization of coded synthetic polymers and observed that the molecular bits that they contain occupy much smaller volumes than do the nucleotides in DNA. "Abiotic sequence-coded polymers are now well beyond proof-of-concept," Lutz says. "We were the first group. Now it is a trend or field in polymer chemistry."
Lutz believes that within the next 10 years, his group will bring anti-counterfeiting and traceability technologies using their precisely tailored polymers to market. Counterfeiting of medical devices is a significant problem. The World Health Organization estimates that more than eight percent of the medical devices in circulation are counterfeits. Lutz's group is building and inserting sequence-defined polymers in medical devices like ocular implants. The polymers can be extracted later and identified by tandem mass spectroscopy.
"When you can store code in a molecule, you can imagine that with a single molecule you can write something, such as the name of a company, a batch number or production date," Lutz says. "You have a molecule that you can directly blend with various materials, such as plastics or ceramics. We could put the molecule in the screen of a smartphone, a medical device or an implant in the body. We could even put it in a pricey luxury bag."
A press conference on this topic will be held Monday, April 1, at 11 a.m. Eastern time in the Orange County Convention Center. Reporters may check-in at the press center, Room W231B, or watch live on YouTube http://bit.ly/ACSLive_Orlando2019 ("ACSLive_Orlando2019" is case-sensitive). To ask questions online, sign in with a Google account.
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The researchers acknowledge support and funding from the French National Research Agency and European Union Horizon 2020.
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Title
Design of high-precision polymers by multistep synthesis
Abstract
Synthetic polymers are usually synthesized by two main mechanisms: chain-growth and step-growth polymerizations. Although useful for large-scale synthesis, both approaches lead in general to polydisperse samples, in which polymer chains have different chain-lengths. Furthermore, when different monomers are copolymerized via these mechanisms, the formed copolymers exhibit chain-to-chain composition- and sequence-deviations. This differs from biological polymerization mechanisms, in which uniform macromolecules with precisely-controlled chain-lengths, tacticity and monomer sequences are formed. Thus, over the past few decades, polymerization methods allowing a better control over macromolecular structure have been thoroughly investigated. For example, advanced chain-growth methods such as living anionic polymerizations and controlled radical polymerizations have opened up numerous opportunities for controlling the microstructure and architecture of synthetic (co)polymers. Yet, although more accurate than conventional polymerization approaches, these methods still lead to non-uniform samples. The next step in polymer chemistry is therefore the synthesis of uniform polymers with fully-controlled primary structures, as found in biology. Yet, classical methods such as chain growth and step-growth polymerizations are not valid options to synthesize such "high-precision polymers" for the simple reasons that are discussed above. The only way to do so is probably to borrow synthesis tools from other disciplines such as biology, biochemistry and organic synthesis. For example, solid-phase iterative chemistry, which was originally developed for peptide synthesis, is a tool of choice for preparing uniform synthetic polymers. In this lecture, I will highlight recent results obtained in my laboratory using such multistep growth strategies. In particular, I will discuss in details the synthesis of information-containing macromolecules; an emerging class of synthetic polymers that show promise for applications in data storage, anti-counterfeiting and traceability technologies.