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Mutation makes bulldogs and Norwich terriers more susceptible to breathing problems

Genomic study points to a faulty gene linked to swelling from edema as a cause of airway obstruction

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IMAGE: Isabel, a Norwich Terrier, standing on a rocky outcropping in Beavertail Wildlife Refuge (Rhode Island, USA). Breeds including the Norwich Terrier are predisposed to developing upper airway disease. view more 

Credit: Marcia A. Sessions

The discovery of a new mutation associated with breathing difficulties in popular dog breeds suggests that shortened skulls causing flat faces is not the only factor that contributes to the condition, but that swelling around the airways from edema may also play a role. Jeffrey Schoenebeck of the University of Edinburgh and colleagues report these findings in a new study published 9th May in PLOS Genetics.

The flat faces of brachycephalic breeds, like French and English bulldogs, are immensely charming, but they also make the dogs more likely to develop a serious respiratory disease called Brachycephalic Obstructive Airway Syndrome (BOAS). Strangely, Norwich terriers can suffer from a similar breathing problem, called Upper Airway Syndrome (UAS), even though they don't have a flat face. The team, led by the University of Edinburgh's Royal (Dick) School of Veterinary Studies, attempted to identify genetic variations linked to these breathing problems that were unrelated to having a shortened skull. They examined and scored the airways of more than 400 Norwich terriers and performed a genome-wide association study to find genes linked to UAS. Their analysis pointed to a mutation in the ADAMTS3 gene, which they discovered is also found in French and English bulldogs. Furthermore, previous studies have linked mutations in the ADAMTS3 gene to edema, which causes swelling from fluid retention, and is a common characteristic in the airways of Norwich terriers with UAS, and bulldogs with BOAS.

The study presents a new way of looking at these respiratory diseases in dogs, where fluid retention in the tissue that lines the airways makes it more likely that dogs with the mutation will develop breathing obstructions. "We conclude that there are additional genetic risk factors, that if inherited, will likely lead to airway disease in dogs regardless of their face shape," stated author Jeffrey Schoenebeck. "The challenge ahead is to integrate these ideas, and implement sensible breeding practices and treatments that consider various health risks including those presented by the mutation of ADAMTS3."

If scientists develop a test for this mutation, then dog breeders can develop better breeding practices to avoid passing on the faulty gene. Additionally, screening for the mutation may help veterinarians identify dogs which are at risk of UAS, and in particular identify the dogs at risk of swelling of their airways after surgical treatment, which is a common, life-threatening post-operative complication.

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Peer-reviewed / Observational study / Animals

In your coverage please use this URL to provide access to the freely available article in PLOS Genetics: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008102

Citation: Marchant TW, Dietschi E, Rytz U, Schawalder P, Hadji Rasouliha S, Gurtner C, et al. (2019) An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndrome. PLoS Genet 15(5): e1008102. https://doi.org/10.1371/journal.pgen.1008102

Funding: This project was funded by Biotechnology and Biological Sciences Research Council (BBS/E/D/20211553, BBS/E/D/30002275) and the Albert Heim Foundation (project no. 105). EAO is funded by the Intramural Program of the National Human Genome Research Institute of the National Institutes of Health, USA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: TL is an associate editor of PLoS Genetics.

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