Researchers report the identification of a small molecule--C10--that enhanced the susceptibility of Mycobacterium tuberculosis (Mtb), which takes a heavy human toll, to the frontline antibiotic isoniazid (INH), prevented selection for INH-resistant mutants, and rendered existing INH-resistant mutants sensitive to the drug, suggesting that antibiotic resistance in Mtb might be reversible.
Article #18-18009: "Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis," by Kelly Flentie et al.
MEDIA CONTACT: Christina L. Stallings, Washington University School of Medicine, St. Louis, MO; tel: 314-286-0276, 917-202-1447; e-mail: stallings@wusm.wustl.edu
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Journal
Proceedings of the National Academy of Sciences