Bottom Line: This study, called a meta-analysis, combined the results of 21 randomized clinical trials with about 83,000 patients to look at whether vitamin D supplementation was associated with reduced risk of cardiovascular disease events such as heart attack or stroke. Some observational studies have suggested an association between low blood levels of vitamin D and an increased risk of cardiovascular disease events. This study reports that compared with placebo, vitamin D supplementation wasn't associated with a reduction in major adverse cardiovascular events (heart attack, stroke or death from cardiovascular disease) or overall death. The results were similar between different doses of vitamin D and for men and women. A limitation of the study is that the definition of major adverse cardiovascular events varied between the clinical trials.
Authors: Mahmoud Barbarawi, M.D., Michigan State University, Flint, and coauthors
Editor's Note: The article contains conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time: https:/