News Release 

How aerobic exercise and resistance training preserves muscle mass in obese older adults

Cell Press

As obesity increases in aging Western populations, frailty--which is exacerbated by obesity--is becoming a greater health concern and a major healthcare cost. Now, researchers report July 3 in the journal Cell Metabolism that combining aerobic exercise and resistance training helps elderly obese individuals preserve muscle mass and reverse frailty as they work to lose weight. Based on a small clinical trial, the study showed that patients who completed these exercises had increased muscle protein synthesis and preserved muscle quality compared to control groups.

In a previous study, Dennis T. Villareal, professor and geriatric endocrinologist at Baylor College of Medicine, hypothesized that resistance training would best complement weight loss for improving physical function in older obese adults. Study participants took part in a weight-management program and were randomly assigned aerobic workouts, resistance training or a combination of both.

Villareal and colleagues were surprised to find that combined aerobic and resistance training improved cardiovascular fitness to the same extent as aerobic training alone and improved muscle strength to the same extent as resistance training alone. They reported in the New England Journal of Medicine in May 2017 (doi: 10.1056/NEJMoa1616338) that combined aerobic and resistance training resulted in the greatest improvement in physical function and reducing frailty in older obese.

However, it was unclear how obese older adults in particular benefitted from aerobic workouts geared toward cardiovascular fitness combined resistance training. In the Cell Metabolism study, the researchers used molecular and cellular techniques to assess changes in their muscle protein synthesis and myocellular quality to examine the mechanisms underlying the obese older adults' improvement in physical function and preservation of lean body mass.

A subset of participants--47 of the original 160--agreed to undergo muscle biopsies before and after six months of lifestyle interventions to see how their muscle tissue was affected. The participants were men and women that averaged between 69 and 72 years of age and more than half were Hispanic/Latinx. Aerobic activities included treadmill walking, stationary cycling, and stair climbing, with participants exercising at approximately 65% of their peak heart rate; resistance training consisted of 1 to 3 sets of 8 to 12 reps on nine upper-body and lower-body weight-lifting machines.

"Our findings indicated that despite negative energy balance from diet-induced weight loss, exercise training in older adults with obesity helps to preserve muscle mass, improve physical function and reduce frailty," Villareal says.

The study found that the participants' muscle protein synthesis rate increased more with resistance training and combined aerobic-resistance exercise than in the control group. The combined aerobic-resistance exercise was also associated with lower expression of genes associated with muscle atrophy and the best preservation of muscle growth regulators, which the researchers hypothesized could also play a role in promoting muscle mass preservation and improvement in physical function in that group.

In the elderly obese, combined aerobic and resistance exercise is superior to either mode independently for maintaining muscle mass during weight-loss therapy, he says. Aerobic and resistance training is the most effective strategy and therefore, Villareal notes, "the best approach."

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This work was supported the National Institutes of Health, the New Mexico Veterans Affairs Health Care System, the Michael E. DeBakey VA Medical Center, and the Albert and Margaret Alkek Foundation.

Cell Metabolism, Colleluori et al.: "Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Calorie Restriction" https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30311-0

Cell Metabolism (@Cell_Metabolism), published by Cell Press, is a monthly journal that publishes reports of novel results in metabolic biology, from molecular and cellular biology to translational studies. The journal aims to highlight work addressing the molecular mechanisms underlying physiology and homeostasis in health and disease. Visit: http://www.cell.com/cell-metabolism. To receive Cell Press media alerts, contact press@cell.com.

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