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Gene linked to a rare neurological disorder regulates key enzyme in Alzheimer's

Mass General Hospital researchers discover that a gene linked to a rare neurological disorder also regulates a key enzyme involved in Alzheimer's disease

Massachusetts General Hospital

BOSTON - A gene that can become mutated and cause a rare balance disorder also regulates the behavior of an enzyme that increases the risk for Alzheimer's disease (AD), according to a new study by researchers at Massachusetts General Hospital (MGH) to be published in the journal Cell on August 22, 2019. This discovery may help to identify new targets for experimental medications designed to delay or stop the onset of AD.

In 2008, neuroscientist Rudolph E. Tanzi, PhD, director of the Genetics and Aging Research Unit and co-director of the McCance Center for Brain Health at MGH, and his colleagues identified several genes that are closely associated with AD. They include ATXN1, which carries the genetic code for producing a protein called ataxin-1. At the time, it was already known that a variation known as a "gain of function" mutation in ATXN1 causes a condition called spinocerebellar ataxia type 1 (SCA1), which afflicts one to two people per 100,000 worldwide. SCA1 leads to loss of coordination and balance, among other symptoms, which can include cognitive problems such as learning and memory difficulties.

However, the ATXN1 mutation that causes SCA1 is not associated with AD, and the role ataxin-1 might play in the disease remained unknown. "So the big question facing us was, How does a gene involved in a balance disorder somehow increase the risk for Alzheimer's disease?" says Tanzi, senior author of the Cell paper.

The answer to that question eventually came by posing another. "We asked whether loss of ataxin-1 function could lead to Alzheimer's disease," says MGH neuroscientist Jaehong Suh, PhD. Suh supervised a team that crossbred mice that were specially bred to have the ATXN1 gene deleted, causing them to lack ataxin-1, with a second group of mice that had been bred to have AD (AD mice). These pairings produced offspring that were missing ataxin-1, which in turn made their levels of an enzyme called beta-secretase 1 (BACE1) to rise dramatically.

BACE1 plays an essential role in the formation of amyloid plaques, which are clusters of damaged nerve cells and other proteins in the brain that are one of the hallmarks of AD. To be sure, mice lacking ataxin-1 had significantly greater deposits of amyloid plaque than the AD mice. They also had higher levels of inflamed brain tissue, formed fewer new neurons in regions associated with memory and learning, and had impaired axons, which are fibers that carry signals between neurons.

"The idea that the same protein will cause one neurodegenerative disease in a 'gain' situation, and cause vulnerability to another neurodegenerative disease in a 'loss' situation, is fascinating," says neurogeneticist Huda Y. Zoghbi, MD, a professor at Baylor College of Medicine, director of the Jan and Dan Duncan Neurological Research Institute in Houston, and a coauthor of the Cell study.

Several experimental drugs that block BACE1 have failed due to toxicity, but discovering ataxin-1's role in regulating this enzyme "could provide a new avenue to safely stop formation of amyloid plaques and potentially prevent this disease before it causes symptoms," says Tanzi.

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The primary authors of the Cell paper are Rudolph E. Tanzi, PhD, director of the Genetics and Aging Research Unit, co-director of the McCance Center for Brain Health at MGH, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School; Huda Y. Zoghbi, MD, a professor at Baylor College of Medicine and director of the Jan and Dan Duncan Neurological Research Institute in Houston; and Jaehong Suh, PhD, assistant professor of neurology at MGH. This study was supported by the Cure Alzheimer's Fund and JPB Foundation.

About the Massachusetts General Hospital

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with an annual research budget of more than $925 million and comprises more than 8,500 researchers working across more than 30 institutes, centers and departments. In August 2018 the MGH was once again named to the Honor Roll in the U.S. News & World Report list of "America's Best Hospitals."

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