image: A rhesus monkey in the primate husbandry at the German Primate Center. view more
Credit: Margrit Hampe
To investigate how information of different visual features is processed in the brain, the neuroscientists from the German Primate Center - Leibniz Institute of Primate Research in Göttingen, Germany, the Iran University of Science and Technology and the Institute for Research in Fundamental Sciences in Tehran, Iran measured the activity of individual nerve cells in the brain of rhesus monkeys, while the animals performed a visual perception task. The monkeys were trained to report changes in moving patterns on a computer screen. Using hair-thin microelectrodes, which are painless for the animals, the researchers measured the electrical activity of groups of nerve cells. These signals continuously oscillate over a broad frequency spectrum.
The scientists recorded the activity in the brain area highly specialized for the processing of visual motion information. Using advanced signal processing techniques, they found that the activity of those nerve cells oscillates at high frequencies (around 200 cycles per second) and that these oscillations are linked to perception. "We observed that faster responses of the animals occurred whenever the nerve cells showed a stronger oscillatory activity at high frequencies, suggesting that these oscillations influence perception and action," explains Stefan Treue, head of the Cognitive Neuroscience Laboratory at the German Primate Center and one of the senior authors of the study.
Previous studies had shown that different visual aspects, such as the color and motion direction of visual objects, are analyzed in highly specialized, anatomically separate brain areas. These areas then transmit their information to high-level brain areas, where individual features are combined to form our unified percept of visual objects. It turns out that the brain region processing color information transmits information via a lower frequency (around 70 cycles per second) than the high-frequency transmission of the brain region processing motion signals. "Our computational analysis shows that high level regions could use these different frequencies to distinguish the source of neural activity representing the different features," explains Mohammad Bagher Khamechian, scientist at the Iran University of Science and Technology in Tehran and first author of the study.
The detailed knowledge of how the brain of rhesus monkeys enables perception as well as other complex cognitive functions provides insights about the same processes in the human brain. "The oscillatory activity of neurons plays a critical role for visual perception in humans and other primates," summarizes Stefan Treue. "Understanding how exactly these activity patterns are controlled and combined, not only helps us to better understand the underlying neural correlates of conscious perception, but also may enable us to gain a better understanding of physiological deficits underlying disorders that involve perceptual errors, such as in schizophrenia and other neurological and neuropsychiatric diseases."
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Original publication
Khamechian MB, Kozyrev V, Treue S, Esghaei M, Daliri MR (2019): Routing information flow by separate neural synchrony frequencies allows for functionally labeled lines in higher primate cortex. PNAS, https://doi.org/10.1073/pnas.1819827116
Contact and suggestion for editors
Prof. Dr. Stefan Treue
Phone: +49 (0) 551 3851-118
Email: streue@dpz.eu
Dr. Moein Esghaei
Tel.: +49 (0) 551 3851-344
E-Mail: aesghaei@dpz.eu
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The German Primate Center (DPZ) - Leibniz Institute for Primate Research conducts biological and biomedical research on and with primates in the fields of infection research, neuroscience and primate biology. The DPZ maintains four field stations in the tropics and is the reference and service center for all aspects of primate research. The DPZ is one of 95 research and infrastructure facilities of the Leibniz Association.
Journal
Proceedings of the National Academy of Sciences