News Release 

Home-based education reduces hospitalizations in patients with atrial fibrillation

HELP-AF study presented in a late breaking science session today at ESC Congress 2019 together with WCC

European Society of Cardiology

Paris, France - 1 Sept 2019: Home-based and personalised education keeps patients with atrial fibrillation out of hospital, according to late breaking results from the HELP-AF study presented today at ESC Congress 2019 together with the World Congress of Cardiology.(1)

Principal investigator Professor Prash Sanders of the University of Adelaide, Australia said: "The initiative was designed to empower patients to understand and take control of their atrial fibrillation, i.e. to improve self-management. Its success in stopping hospital admissions has enormous implications for the delivery of care in atrial fibrillation. As healthcare costs grow due to hospitalisations, such programmes are essential."

Over the last few decades, the number of people living with atrial fibrillation around the world has grown exponentially. This is because populations are getting older and acquiring lifestyle related conditions such as high blood pressure, obesity, sleep apnoea and diabetes that raise the risk of developing atrial fibrillation. Atrial fibrillation is now a more common cause of presenting to hospital than heart failure or heart attacks.

Prof Sanders said: "Some hospital admissions for atrial fibrillation are likely preventable through better education of those living with the condition. We believed that involving patients in their care, helping them understand their condition, and providing tools to manage it might avoid hospitalisations. This led us to do the HELP-AF study, which looked at the impact of home-based education on hospitalisation and quality of life."(2)

The study enrolled 627 patients with atrial fibrillation presenting to the emergency department of six hospitals in Adelaide, South Australia. Patients were randomised to the HELP-AF programme or usual care. Patients were approached to participate within two months of their emergency department presentation.

Patients allocated to the intervention received two educational home visits by a nurse or pharmacist: one approximately two weeks after enrolment and the second six weeks after that. Patients received a booklet for future reference. Education was delivered in a structured way and focused around four messages: 1) management of future atrial fibrillation episodes; 2) importance of medicines to manage symptoms and stroke risk; 3) appropriate use of stroke prevention medicines; and 4) role of lifestyle modification. Messages were personalised to target areas where behaviour change was needed.

Patients were followed up for two years for the primary endpoints of all-cause unplanned hospitalisation and health-related quality of life evaluated by the 36-Item Short Form Health Survey (SF-36).

At 24 months, total unplanned hospitalisations were 233 in the HELP-AF group and 323 with usual care with an incident rate ratio of 0.74 (95% confidence interval 0.62-0.89; p=0.001). After multivariable adjustment, the intervention reduced total unplanned hospitalisations by 26%, atrial fibrillation related hospitalisations by 31%, and other cardiovascular hospitalisations by 49%, while having no impact on non-cardiac hospitalisations.

There was no difference in health-related quality of life using the SF-36 survey, which is a generic health survey. Using a more specific questionnaire, the Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT), there was gradual improvement in quality of life measures over time in both groups. This reached significance at 24 months in two subcategories of the "Symptoms" and "Treatment Concern" domains, in favour of the intervention.

Prof Sanders said several components of the scheme likely contributed to the fall in hospitalisations:

  • Education was delivered in the comfort of the patient's home using language they could understand and focusing on areas important to them.
  • Patients received a booklet as an ongoing reminder of the four messages.
  • The material listed questions patients could discuss with their physician to help manage their disease.
  • The booklet outlined the "REST plan" for patients to follow during atrial fibrillation episodes to avoid going to hospital. This included developing an emergency management plan with their physician and a dedicated telephone service for advice from a cardiologist.

Prof Sanders said: "The study shows that education delivered in a structured and individualised way within the patient's home has a dramatic impact not only on hospitalisations for atrial fibrillation but on all cardiovascular hospitalisations."

The design of the intervention makes it easy to replicate in other countries and settings, noted Prof Sanders. Nurses and pharmacists were trained in a structured educational visiting approach and upskilled in atrial fibrillation management. "It was personalised education using a structured delivery method," he said.

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Notes to editors

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Funding: This study was supported by a South Australian Cardiovascular Research Network Grant jointly funded by the National Heart Foundation and the Government of South Australia.

Disclosures: Financial disclosures: Dr Sanders is supported by a Practitioner Fellowship from the National Health and Medical Research Council of Australia and by the National Heart Foundation of Australia. Dr Hendriks is by the Derek Frewin Lectureship from the University of Adelaide and a Future Leader Fellowship from the National Heart Foundation of Australia. Drs Gallagher and Middeldorp are supported by Fellowships from the University of Adelaide. Dr Mahajan is supported by a Fellowship from the National Health and Medical Research Council of Australia. Dr Lau is supported by the Robert J. Craig Lectureship from the University of Adelaide. Conflict of Interest Disclosures: Dr Sanders reports having served on the advisory board of Medtronic, Abbott Medical, Boston Scientific, CathRx and PaceMate. Dr Sanders reports that the University of Adelaide has received on his behalf lecture and/or consulting fees from Medtronic, Abbott Medical, and Boston Scientific. Dr Sanders reports that the University of Adelaide has received on his behalf research funding from Medtronic, Abbott Medical, Boston Scientific, and Microport. Dr Hendriks reports that the University of Adelaide has received on his behalf lecture and/or consulting fees from Medtronic and Pfizer/BMS. Dr Brooks accepted a continuing position at Microport CRM subsequent to the design and commencement of the study. Dr Beltrame reports having received research funding from AstraZeneca. All other authors report no conflicts.

References and notes

(1) The abstract "A home-based education and learning program for atrial fibrillation: the HELP-AF study" will be presented during the session Late Breaking Science in Atrial Fibrillation 2 on Sunday 1 September at 11:00 to 12:30 CEST in room Berlin - Village 4.

(2) HELP-AF study: Home-based structured and personalised patient Education and Learning Programme for AF.

About ESC Congress

ESC Congress is the world's largest gathering of cardiovascular professionals contributing to global awareness of the latest clinical trials and breakthrough discoveries. ESC Congress 2019 together with the World Congress of Cardiology takes place from 31 August to 4 September at the Expo Porte de Versailles in Paris, France. Explore the scientific programme. http://spo.escardio.org/default.aspx?eevtid=1423

About the European Society of Cardiology

The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.

This press release accompanies a presentation at ESC Congress 2019 together with the World Congress of Cardiology. It does not necessarily reflect the opinion of the European Society of Cardiology.

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