News Release 

The FASEB Journal: IGF1 gene is essential to adult tendon growth, animal study shows

Federation of American Societies for Experimental Biology

Tendon injuries are among the most common injuries seen in athletes at all levels, from weekend warriors to professional basketball players. For those who rupture their tendons, returning to the same level of physical activity they enjoyed before the injury is rare.

Not a lot is known about how tendons adapt, or how they recover when injured. A recent animal study in The FASEB Journal, however, identified that a molecule called insulin-like growth factor 1 (IGF1) plays an important role in allowing tendons to adapt to physical activity, and is required for tendons to grow properly.

Using advanced genetic techniques in a mouse model, researchers removed the IGF1 gene from tendons and monitored how the mice responded to physical activity. They found that removal of IGF1 prevented the tendons from growing and adapting like they normally would. The researchers performed further studies in tendon cells to determine how IGF1 was working to cause tendons to grow.

"We are excited about the findings of this study, which shows the critical role of IGF1 in tendon growth," said Christopher Mendias, PhD, Associate Professor, Hospital for Special Surgery, and Adjunct Associate Professor of Orthopaedic Surgery, University of Michigan. "These findings provide important scientific rationale for pursuing IGF1 and the related human growth hormone in the treatment of tendon disorders."

Human growth hormone, or HGH, is an available drug that acts by increasing the levels of IGF1 in the body. Data from this and several other studies suggests that HGH might be beneficial in improving the treatment of tendons by helping restore them to pre-injury levels of functionality and minimizing scar tissue formation.

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The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). The world's most cited biology journal according to the Institute for Scientific Information, it has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 29 societies with more than 130,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB's mission is to advance health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to member societies and their members.

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