Taking a 'fingerprint' of the mix of bacteria in the gut can indicate how susceptible individual cancer patients are to gut damage as a result of radiotherapy for prostate and gynaecological cancers, a new study shows.
Researchers showed that having a reduced diversity of gut bacteria was associated with an increased risk of both immediate and delayed damage to the gut following radiotherapy.
If patients at higher risk of gut side effects could be identified before radiotherapy, they could be given procedures such as faecal transplants to treat or even prevent damage.
A team at The Institute of Cancer Research, London, The Royal Marsden NHS Foundation Trust and Imperial College London studied the bacterial fingerprint and faecal samples of 134 patients at different stages pre and post radiotherapy to the prostate and pelvic lymph nodes.
Their study, published today (Wednesday) in Clinical Cancer Research, aimed to see if there was a difference in the combination of gut bacteria among patients who suffered gut damage following radiotherapy compared with those who didn't.
The research was funded by the NIHR Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research (ICR) and the Calouste Gulbenkian Foundation.
The gut microbiota contains the largest number of 'good bacteria' in the human body, playing a vital role in helping digest food and keep the digestive system healthy. Each person has a different bacterial microbiome that is unique to their gut, like a bacterial fingerprint.
The researchers were interested in assessing the role the microbiota plays in patients' response to radiotherapy - given that around 80 per cent of patients report a change in bowel habit after pelvic radiotherapy, and that 10 to 25 per cent have significant, long-term damage to their gut which impairs their quality of life.
Damage to the gut can often lead to bleeding, diarrhoea, abdominal pain, nausea and weight loss, and can occur both early (during or shortly after radiotherapy), or late (from around three months afterwards).
The researchers found that patients who had a high risk of gut damage had 30-50 per cent higher levels of three bacteria types, and lower overall diversity in their gut microbiome, than patients who had not undergone any radiotherapy.
This suggests that patients with less diverse gut microbiomes and high levels of the bacteria - Clostridium IV, Roseburia and Phascolarctobacterium - are more susceptible to gut damage.
The researchers also believe these patients may require more 'good bacteria' to maintain a healthy gut - and so may be more susceptible to side effects when these bacteria are killed by radiation.
The new research is the first to explore the protective effects of the microbiome in people and at preventing the late effects of radiotherapy. The next stage will be to explore whether it is possible to treat or prevent gut damage in people with high-risk microbiome fingerprints - potentially by giving them faecal transplants, or by altering the dose of radiation given.
Professor David Dearnaley, Professor of Uro-Oncology at The Institute of Cancer Research, London, and Consultant Clinical Oncologist at The Royal Marsden NHS Foundation Trust, said:
"Radiotherapy to the prostate and pelvic lymph nodes is an important way to manage cancer but it can result in damage to the gut and unpleasant side effects for the patient, which can often be long-lasting and quite severe.
"Our study is the first to show that gut bacteria have an important influence on how susceptible patients are to gastrointestinal side effects from radiotherapy. We still need to do further studies to confirm the role of good bacteria, but if we can identify patients at the highest risk of gut damage we could intervene to control, treat or even prevent the side effects of radiation. If microbial treatments such as faecal transplants are found to reduce damage, for example, it could substantially improve patients' quality of life."
Notes to editors
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The Institute of Cancer Research, London, is one of the world's most influential cancer research organisations.
Scientists and clinicians at The Institute of Cancer Research (ICR) are working every day to make a real impact on cancer patients' lives. Through its unique partnership with The Royal Marsden NHS Foundation Trust and 'bench-to-bedside' approach, the ICR is able to create and deliver results in a way that other institutions cannot. Together the two organisations are rated in the top centres for cancer research and treatment globally.
The ICR has an outstanding record of achievement dating back more than 100 years. It provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today it is a world leader at identifying cancer-related genes and discovering new targeted drugs for personalised cancer treatment.
A college of the University of London, the ICR is the UK's top-ranked academic institution for research quality, and provides postgraduate higher education of international distinction. It has charitable status and relies on support from partner organisations, charities and the general public.
The ICR's mission is to make the discoveries that defeat cancer.
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The National Institute for Health Research (NIHR) is the nation's largest funder of health and care research. The NIHR:
- Funds, supports and delivers high quality research that benefits the NHS, public health and social care
- Engages and involves patients, carers and the public in order to improve the reach, quality and impact of research
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About Imperial College London
Imperial College London is one of the world's leading universities. The College's 17,000 students and 8,000 staff are expanding the frontiers of knowledge in science, medicine, engineering and business, and translating their discoveries into benefits for our society.
Imperial is the UK's most international university, according to Times Higher Education, with academic ties to more than 150 countries. Reuters named the College as the UK's most innovative university because of its exceptional entrepreneurial culture and ties to industry.