News Release 

Is bipolar disorder associated with increased risk of Parkinson's disease?

JAMA Neurology

Bottom Line:  This study, called a systematic review and meta-analysis, combined the results of seven studies with 4.3 million participants to examine a potential association between bipolar disorder with a later diagnosis of Parkinson disease of unknown cause. The findings suggest that a previous diagnosis of bipolar disorder was associated with increased likelihood of a subsequent Parkinson disease diagnosis but subgroup analyses suggest the possibility of an overestimation of the magnitude of the associations. The main limitation of the study is analysis that suggests a greater likelihood of a Parkinson disease diagnosis in shorter studies which raises concerns over misdiagnosis.

To access the embargoed study: Visit our For The Media website at this link

Authors: Joaquim J. Ferreira, M.D., Ph.D., Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, and coauthors.


Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


Media Advisory: To contact corresponding author Joaquim J. Ferreira, M.D., Ph.D., email The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.