News Release 

Study suggests interventions against frailty

PLOS

Interventions aimed at reducing obesity and sedentary behavior, increasing intensity of physical activity, and improving success of smoking cessation tools have the potential to reduce the incidence of frailty, according to a study published October 30, 2019 in the open-access journal PLOS ONE by Nils Niederstrasser of de Montfort University, UK, and colleagues.

Frailty is a common geriatric state which affects roughly 10% of over 65 year olds and occurs as a consequence of age-related physiological decline in multiple organ systems. Frailty leads to a greater risk of adverse health outcomes including reduced functional independence, increased disability, poor quality of life, dementia, institutionalization and mortality. Studies investigating both the progression and incidence of frailty in the same population have been scarce, which has made it difficult to pinpoint modifiable risk factors that might delay or reduce the progression of frailty.

In the new study, researchers used data from participants aged 50 and over from the English Longitudinal Study of Ageing (ELSA). They integrated the data into a 56-item multidimensional frailty index (FI) comprised of self-reported health condition, disabilities, cognitive function, hearing, eyesight, depressive symptoms and ability to carry out activities of daily living. Frailty development was studied in 7,420 study participants and frailty progression over 12-years follow up in another 8,780 study participants.

Age was the strongest predictor of frailty. However, other variables, including modifiable risk factors, were independently associated with frailty. Being in the lowest wealth quintile, lack of educational qualifications, obesity, a high waist-hip ratio, being a current or previous smoker, pain, sedentary behavior, and lower body strength were all significant risk factors for frailty progression and incidence.

The strengths of the study included the use of a large representative sample of older adults, the use of the multidimensional frailty index, and the follow-up period of 12 years. However, the current frailty index did not contain deficits pertaining to social frailty, such as perceived social isolation or loneliness.

Niederstrasser adds: "By making lifestyle changes such as becoming more active, quitting smoking, and losing weight, a person may dramatically reduce their chance of becoming frail. For example, a person who does not smoke and is physically active has half the risk of becoming frail compared to a person who is physically inactive and smokes."

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Citation: Niederstrasser NG, Rogers NT, Bandelow S (2019) Determinants of frailty development and progression using a multidimensional frailty index: Evidence from the English Longitudinal Study of Ageing. PLoS ONE 14(10): e0223799. https://doi.org/10.1371/journal.pone.0223799

Funding: This work was supported by grant number 689592 "my-AHA" from the Horizon 2020 research funding framework of the European Commission (https://ec.europa.eu/programmes/horizon2020/en). The data were made available through the UK Data Archive. The English Longitudinal Study of Ageing was developed by a team of researchers based at the University College London, NatCen Social Research, the Institute for Fiscal Studies and the University of Manchester. The data were collected by NatCen Social Research. The funding is provided by the National Institute of Aging (R01AG017644) and a consortium of UK government departments coordinated by the Economic and Social Research Council. The funders had no role in the study design; in the collection, analysis and interpretation of data; in writing of the report; or in the decision to submit the paper for publication. The developers and funders of ELSA and the Archive do not bear any responsibility for the analyses or interpretations presented here.

Competing Interests: The authors have declared that no competing interests exist.

In your coverage please use this URL to provide access to the freely available article in PLOS ONE: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223799

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