News Release 

Experts call for coordinated action to avert a brain disease crisis

Queen Mary University of London

Experts are calling for a public health campaign aimed at promoting a 'brain-healthy lifestyle' to reduce the risk of developing neurodegenerative brain diseases, such as Alzheimer's disease and Parkinson's disease.

The campaign should support existing health promotion work by emphasising that "what is good for the heart is generally good for the brain," they urge.

In a report published by the Oxford Health Policy Forum today, they go on to talk about a 'window of opportunity' in midlife where individuals may be able to make the biggest difference to their risk of developing neurodegenerative disease or of delaying its progress.

The public education campaign should be underpinned by a coordinated research programme, which is aimed at developing clinical tests for identifying those at risk of developing neurodegenerative diseases ? before signs and symptoms appear. Research to develop new treatments and other tests to facilitate earlier diagnosis must also continue, and health systems must prepare now for the time when such tests are available.

"People need to understand the risk factors that can affect their brain health and what can be done to maintain it and to help prevent neurodegenerative diseases," said neurologist Professor Gavin Giovannoni from Queen Mary University of London and Co-chair of the author group of a new evidence-based report, Time matters: a call to prioritize brain health.

The report summarises published evidence and the consensus findings of an international multidisciplinary expert group, including clinicians, researchers and representatives from patient advocacy and professional groups.

"Deterioration in the structure or function of nerve cells (neurodegeneration) begins many years before any symptoms become obvious. This means that diagnosis often occurs at a relatively late stage in the disease course, when substantial damage to nerve cells has already taken place," explained Dr Alastair Noyce, from Queen Mary University of London and Co-chair of the author group.

"We conclude that there is a '10-20-year window of opportunity' in midlife during which people can reduce the risk of developing a neurodegenerative disease or delay its progress. We cannot change our genetic make-up, but we can help reduce the risk of developing neurodegenerative diseases ourselves by taking exercise, keeping socially active, eating healthily, reducing alcohol intake, stopping smoking and keeping our brains active."

Neurodegenerative diseases are becoming more common as people live longer, but they are not an inevitable consequence of normal ageing. Worldwide, Alzheimer's disease affects about 50 million people and Parkinson's disease affects more than 6.1 million people; these numbers are rising.

"Planning for the healthcare structures of the future has to start now if we're to avert a crisis," stressed Professor Giovannoni. "Neurodegenerative diseases pose an enormous socioeconomic and individual burden, and this will continue to grow as the population ages."

The report sets out a series of consensus recommendations, including:

  • improve public understanding of how to protect brain health through lifestyle measures - such as exercise and a healthy diet

  • prepare for the likely increased demand for genetic testing by those wanting to understand their risk of a neurodegenerative disease

  • provide access to available and effective treatments in a timely manner

  • provide accessible holistic care, including prevention information, treatment options and support

  • conduct research to identify accurate and cost-effective tests for disease detection and diagnosis

  • develop, validate and approve tests, tools and apps for monitoring brain health.

Several professional associations and advocacy groups - including European Brain Council, Alzheimer's Research UK, Parkinson's UK and European Parkinson's Disease Association - have endorsed the recommendations.

Welcoming the report, Dr Hilary Evans, Chief Executive of Alzheimer's Research UK, said: "Evidence shows that what's good for the heart is good for the brain, but this message is yet to hit home with the public. Only a third of people think it's possible to reduce their risk of dementia, and we must do more to empower people with knowledge about the actions they could take to protect their brain health.

Alzheimer's Research UK wholeheartedly supports the timely and important recommendations of this report."

Representing the European Brain Council, Professor Monica Di Luca echoed the need for action and collaboration: "The European Brain Council has for years been highlighting the importance and cost of brain diseases. This report strengthens the case for governments to prioritise brain health and to prepare for the challenges that healthcare systems will face as the burden of brain disease continues to increase."

###

Time matters: a call to prioritize brain health was launched at the European Health Forum Gastein conference (the 'Davos' for Public Health) on Thursday 3 October.

Preparation of the report was funded by educational grants from Biogen and F. Hoffmann-La Roche, who had no influence on the content.

More information

Chris Mahony, Interim Faculty Communications Executive (Medicine and Dentistry) Marketing and Communications Department, Queen Mary University of LondonT: 0207 8825315 E: c.mahony@qmul.ac.uk

Notes to editors

Lead author and Chair, Professor Gavin Giovannoni, and other members of the author group are available for interview.

Professor Gavin Giovannoni is centre lead for neuroscience and trauma at the Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London.

Professor Philip Scheltens, a leading expert in Alzheimer's disease and Co-chair of the report, is based at the Alzheimer Center Amsterdam, Amsterdam University Medical Centers, Netherlands.

Author and Co-chair of the report, Dr Alastair Noyce, is a Clinical Senior Lecturer, at Queen Mary University of London and a Neurology Registrar at Barts. His main research interests are in the area of Parkinson's disease.

Time matters: a call to prioritize brain is published by Oxford Health Policy Forum CIC, a not-for-profit community interest company registered in England and Wales (Registration number: 10475240).

A full copy of the report is available at http://www.oxfordhealthpolicyforum.org

About Queen Mary University of London

At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.

In 1785, Sir William Blizard established England's first medical school, The London Hospital Medical College, to improve the health of east London's inhabitants. Together with St Bartholomew's Medical College, founded by John Abernethy in 1843 to help those living in the City of London, these two historic institutions are the bedrock of Barts and The London School of Medicine and Dentistry.

Today, Barts and The London continues to uphold this commitment to pioneering medical education and research. Being firmly embedded within our east London community, and with an approach that is driven by the specific health needs of our diverse population, is what makes Barts and The London truly distinctive.

Our local community offer to us a window to the world, ensuring that our ground-breaking research in cancer, cardiovascular and inflammatory diseases, and population health not only dramatically improves the outcomes for patients in London, but also has a far-reaching global impact.

This is just one of the many ways in which Queen Mary is continuing to push the boundaries of teaching, research and clinical practice, and helping us to achieve the previously unthinkable.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.