News Release 

Digital sepsis monitoring system helps save lives and improves care

Imperial College London

The introduction of a digital alert system to monitor patients with sepsis has led to a reduction in deaths and hospital stays.

Sepsis, also known as blood poisoning, is life threatening and accounts for an estimated 46,000 deaths in the UK each year. If diagnosed early it can be treated effectively with antibiotics but the difficulty lies in spotting sepsis before it develops, as symptoms are similar to other illnesses such as flu.

The introduction of the digital sepsis alert system at Imperial College Healthcare NHS Trust in 2016 was associated with lower odds of death, shorter hospital stays and increased odds of receiving timely antibiotics.

The system monitors a range of changes in patients such as temperature, heart rate and glucose levels and alerts doctors and nurses if they fall outside safe parameters so they can investigate further. Clinicians are notified of patients who have triggered the alert either through a pop-up warning on their electronic health records and/or on a dashboard, which highlights any patient with an active alert when they open a patient's record.

In addition to the alert, Imperial College Healthcare NHS Trust designed a multidisciplinary care plan which is launched in the electronic patient record system when a clinician confirms a diagnosis of sepsis. This prompts the clinical team to determine the best options from a range of treatments, such as fluids, oxygen, diagnostic tests and early antibiotics, and ensure they are given to patients within one hour - in line with national targets.

The study, led by researchers at Imperial College London and published in the Journal of the American Medical Informatics Association, is the first evaluation of a digital sepsis alert system in a British hospital trust and the largest undertaken anywhere to date.

Dr Kate Honeyford, from the Global Digital Health Unit at Imperial College London and lead author of the research, said:

"Sepsis can be deadly if it's not diagnosed and treated quickly. However, symptoms can be hard to spot and are similar to other conditions such as flu or a chest infection, which can result in delayed diagnosis and treatments. The sepsis alert system was put in place at Imperial College Healthcare NHS Trust to see if it can help monitor and flag patients who may have sepsis to clinicians for further investigations and treatments. Often digital systems are implemented but research on their performance is not done. Our study shows for the first time that robust analysis of a digital alert system was associated with improvements in outcomes for patients and the system presents an opportunity to improve care for patients who may have sepsis."

Dr Ceire Costelloe, Director of Imperial's Global Digital Health Unit and co-author of the study, said: "There is a drive towards creating innovative digital technology that will meet the needs of patients and clinicians in the NHS. Our study shows that the sepsis alert system could be an example of this. The results are encouraging and we will be carrying out further work to see if the alert system has the same impact on a wider group of patients."

Dr Anne Kinderlerer, Consultant Rheumatologist at Imperial College Healthcare NHS Trust and co-author of the study, added:

"At Imperial College Healthcare NHS Trust we are focused on improving our ability to recognise and treat sepsis more quickly and effectively. The findings from this study show that the alert has made a significant impact on identifying more cases of sepsis and reducing the number of patients who die in hospital as a result. More patients are surviving sepsis at our hospitals and it is testament to the alert and treatment plans we have working hand in hand to help us ensure that patients are treated with antibiotics and other interventions in order to save more lives. Our plan is now to roll this alert system out across the Trust in different health specialities so that we can further reduce the toll and impact that sepsis has on our patients."

The digital sepsis alert system was developed by Cerner and it was introduced at Imperial College Healthcare NHS Trust's hospitals in 2016 within emergency departments and inpatient wards.

The team analysed data of more than 27,000 hospital stays of patients who had triggered the alert system between October 2016 and May 2018. These patients were in emergency departments as well as acute and haematology wards at St Mary's Hospital, Charing Cross Hospital and Hammersmith Hospital, part of Imperial College Healthcare NHS Trust.

The team found that patients who triggered the alert had 24 per cent lower odds of in hospital death as well as a 35 per cent increased chance of receiving timely antibiotics than a group of patients who were receiving the usual standard care, where the digital alert system is not involved. They also found that patients who were admitted to hospital had a 4 per cent lower chance of staying in hospital for more than seven days than patients with similar symptoms, than the group of patients who were receiving standard care.

The team suggests the alert system has been able to alert clinicians to deteriorating conditions in patients and, as a result, investigations and treatment plans have been implemented more quickly.

The team will now carry out a larger study involving more NHS hospitals to see whether the results are the same in a bigger patient group.

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The study was funded by NIHR Imperial Biomedical Research Centre.

For more information, please contact:

Maxine Myers
AHSC Communications Manager
Imperial College AHSC
Email: Maxine.myers@imperial.ac.uk
Tel: +44 (0)7561451724

Out of hours duty media officer: +44 (0)7803 886 248

1. About Imperial College Academic Health Science Centre (AHSC)

The AHSC is a partnership between Imperial College London, The Institute of Cancer Research, Imperial College Healthcare NHS Trust, Royal Brompton & Harefield NHS Foundation Trust and the Royal Marsden NHS Foundation Trust, based in West London.

Established in 2007, it was the first AHSC to be created in the UK and was formally designated by the Department of Health in 2009.

The partnership brings together multi-disciplinary research and education from across all faculties at the College with the resources and critical mass of the three Trusts to advance discovery and innovation within healthcare.

The purpose of Imperial College AHSC is to utilise excellence in research and education to transform health outcomes, and support the UK's globally competitive position in healthcare related industries by increasing societal and economic gain.

The AHSC is nested within Imperial College Health Partners, the Academic Health Science Network for North West London, which will ensure that discoveries and innovations are applied on a national and global scale.

2. About Imperial College London

Imperial College London is one of the world's leading universities. The College's 16,000 students and 8,000 staff are expanding the frontiers of knowledge in science, medicine, engineering and business, and translating their discoveries into benefits for society.

Founded in 1907, Imperial builds on a distinguished past - having pioneered penicillin, holography and fibre optics - to shape the future. Imperial researchers work across disciplines to improve health and wellbeing, understand the natural world, engineer novel solutions and lead the data revolution. This blend of academic excellence and its real-world application feeds into Imperial's exceptional learning environment, where students participate in research to push the limits of their degrees.

Imperial collaborates widely to achieve greater impact. It works with the NHS to improve healthcare in west London, is a leading partner in research and education within the European Union, and is the UK's number one research collaborator with China.

Imperial has nine London campuses, including its White City Campus: a research and innovation centre that is in its initial stages of development in west London. At White City, researchers, businesses and higher education partners will co-locate to create value from ideas on a global scale. http://www.imperial.ac.uk

3. About Imperial College Healthcare NHS Trust

Imperial College Healthcare NHS Trust is one of the largest hospital Trust's in England, providing acute and specialist healthcare for a population of nearly two million people. The Trust has five hospitals - Charing Cross, Hammersmith, Queen Charlotte's & Chelsea, St Mary's and The Western Eye - as well as community services.

4. About the National Institute for Health Research (NIHR)

The National Institute for Health Research (NIHR) is the nation's largest funder of health and care research. The NIHR:

  • Funds, supports and delivers high quality research that benefits the NHS, public health and social care
  • Engages and involves patients, carers and the public in order to improve the reach, quality and impact of research
  • Attracts, trains and supports the best researchers to tackle the complex health and care challenges of the future
  • Invests in world-class infrastructure and a skilled delivery workforce to translate discoveries into improved treatments and services
  • Partners with other public funders, charities and industry to maximise the value of research to patients and the economy

The NIHR was established in 2006 to improve the health and wealth of the nation through research, and is funded by the Department of Health and Social Care. In addition to its national role, the NIHR supports applied health research for the direct and primary benefit of people in low- and middle-income countries, using UK aid from the UK government.

This work uses data provided by patients and collected by the NHS as part of their care and support and would not have been possible without access to this data. The NIHR recognises and values the role of patient data, securely accessed and stored, both in underpinning and leading to improvements in research and care.

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