News Release 

Clinical trial in Australia tests effectiveness of naloxone by nose vs. injection for opioid overdose

JAMA Network Open

What The Study Did: A randomized clinical trial in Australia tested whether a dose of naloxone administered through the nose was as effective as the same dose delivered by injection to reverse opioid overdose as measured by the need for a rescue dose delivered by injection 10 minutes after the initial treatment. The study included 197 clients at a medically supervised injecting center in Sydney where eligible patients (18 or older with a history of injecting drug use) are allowed to inject drugs under the supervision of clinically trained staff who watch for signs of overdose.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

Authors: Paul Dietze, Ph.D., of the Burnet Institute in Melbourne, Australia, is the corresponding author.

(doi:10.1001/jamanetworkopen.2019.14977)

Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

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Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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