News Release 

Problem drinkers have higher 'benzo' use, UCSF-Kaiser Permanente study shows

Alcohol with Xanax, Valium, Ativan increases risks for overdose, accidents, falls

University of California - San Francisco

Problem drinkers are more likely than teetotalers and moderate drinkers to take benzodiazepines, a class of sedatives that are among the most commonly prescribed drugs -- and the most abused. When taken by heavier drinkers, benzodiazepines may heighten the risk for overdoses and accidents as well as exacerbate psychiatric conditions.

In a study by UC San Francisco and Kaiser Permanente Northern California, researchers found that primary care patients with "unhealthy alcohol use" had a 15 percent higher likelihood of using benzodiazepines than moderate drinkers and nondrinkers. Benzodiazepines -- colloquially known as "benzos" -- are usually prescribed for anxiety and insomnia, and include Valium (diazepam), Xanax (alprazolam), Klonopin (clonazepam), Ativan (lorazepam), Restoril (temazepam) and others.

In the study, which appears in the American Journal of Managed Care on Dec. 13, 2019, researchers reviewed the health records of more than two million primary care patients, who were Kaiser Permanente enrollees. The patients were screened for unhealthy alcohol use, defined as at least 15 drinks per week for men under 65, and at least eight drinks a week for women and males aged 65 and older. They found that 4 percent of the patient pool had unhealthy alcohol use and 7.5 percent of the patient pool had filled a prescription for a benzodiazepine within the last 12 months. The researchers excluded patients who had been prescribed benzodiazepines for alcohol withdrawal.

However, the authors also found that when problem drinkers were prescribed benzodiazepines, their average dose was 40 percent lower and the duration of use was 16 percent shorter than moderate drinkers and abstainers. It is unknown whether the impetus for this regimen came from the prescribing physician or the patients themselves, who "voluntarily limited their use of benzodiazepines to avoid functional impairment," the authors noted.

Patients May Believe Daily Benzos 'Harmless'

"Some physicians may be refilling prescriptions, unaware that their patients have unhealthy alcohol use. In many cases, patients have been taking benzodiazepines for years and believe them to be harmless," said first author Matthew Hirschtritt, MD, clinical professor in the UCSF Department of Psychiatry.

"When benzodiazepines are consumed with alcohol, overdose can result from the impact of two central nervous system depressants. Their effects can reduce motor coordination, impact judgment and decision-making, and result in falls and accidents. Long-term use can lead to cardiovascular, gastrointestinal, liver, kidney and neurological injury, as well as psychosis or suicidal ideation for those with pre-existing psychiatric conditions," he said.

Numerous studies have already demonstrated that long-term benzodiazepine use has been linked to an increased risk for dementia. "It's possible that unhealthy alcohol use may amplify this dementia risk," said Hirschtritt, who is also an associate physician in the Department of Psychiatry of The Permanente Medical Group and an adjunct investigator in the Kaiser Permanente Division of Research.

Alcohol Implicated in 1 in 5 Benzo-Related Deaths

Between 1996 and 2013, the percentage of U.S. adults who filled a benzodiazepine prescription increased from 4.1 percent to 5.6 percent, and the number of overdose deaths involving the drugs spiraled from 0.58 to 3.07 per 100,000 adults. Alcohol was a factor in one-in-four benzodiazepine-related visits and one-in-five benzodiazepine-related deaths in U.S. emergency departments, according to the Centers for Disease Control and Prevention.

The finding that patients with unhealthy alcohol use were 15 percent more likely to be prescribed a benzodiazepine runs counter to the researchers' hypothesis they would have a lower likelihood of obtaining the drugs. "In prescribing drugs, physicians weigh the risks and benefits," said Hirschtritt. "While the risks of benzodiazepines for all patients, and especially those with problem alcohol use, are becoming clearer, their benefits may appear to be negligible given that safer prescription drugs are effective for treating anxiety."

"As we learn more about drinking habits of primary care patients, especially among vulnerable populations such as benzodiazepine users, providers and health systems can better tailor practices and focus identification and prevention efforts," said senior author Stacy Sterling, DrPH, MSW, research scientist at the Division of Research, Kaiser Permanente Northern California.

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Co-Authors: Vanessa Palzes, MPH, and Andrea Kline-Simon, MS, of Kaiser Permanente Northern California; Cynthia Campbell, PhD, MPH, of Kaiser Permanente Northern California and UCSF; and Kurt Kroenke, MD, of Indiana University School of Medicine, Regenstrief Institute and VA Health Services Research and Development in Indianapolis.

Funding: The research was supported by a grant from the National Institute on Alcohol Abuse and Alcoholism.

Disclosures: The authors report no conflicts of interest.

About UCSF: The University of California, San Francisco (UCSF) is exclusively focused on the health sciences and is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. UCSF Health, which serves as UCSF's primary academic medical center, includes top-ranked specialty hospitals and other clinical programs, and has affiliations throughout the Bay Area. Learn more at https://www.ucsf.edu, or see our Fact Sheet.

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