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The Lancet Child & Adolescent Health: Mental health problems persist in adolescents five years after bariatric surgery despite substantial weight loss

The Lancet

Long-term study of adolescent mental health following bariatric surgery suggests that although the surgery can improve many aspects of health, alleviation of mental health problems should not be expected, and a multidisciplinary team should offer long-term mental health support after the operation.

Five years after weight-loss surgery, despite small improvements in self-esteem and moderate improvements in binge eating, adolescents did not see improvements in their overall mental health, compared to peers who received conventional obesity treatment, according to a study in Sweden with 161 participants aged 13-18 years published in The Lancet Child & Adolescent Health journal.

The number of bariatric procedures in adolescents with severe obesity is rapidly increasing. Previous research has shown that bariatric surgery is safe and effective in adolescents, and the 2018 guidelines from the American Society for Metabolic and Bariatric Surgery state that this type of surgery should be considered the standard of care in adolescents with severe obesity.

However, a substantial minority of adolescents with severe obesity have coexisting mental health problems and little is known about the long-term mental health consequences of bariatric surgery. Those who seek surgery might hope to see symptoms improve as a result of weight loss, but long-term outcomes are relatively unknown. A 2018 study found no alleviation of mental health disorders when adolescents were questioned two years following surgery. The new study is the first to take a longer-term view and to use records of psychiatric drug prescriptions and of specialist care for mental health disorders, in combination with self-reported data.

"The transition from adolescence to young adulthood is a vulnerable time, not least in adolescents with severe obesity," says Dr Kajsa Järvholm from Skåne University Hospital, Sweden. "Our results provide a complex picture, but what's safe to say is that weight-loss surgery does not seem to improve general mental health. We suggest that adolescents and their caregivers should be given realistic expectations in advance of embarking on a surgical pathway, and that as adolescents begin treatment, long-term mental health follow-up and support should be a requirement." [2]

In the study, participants were aged 13-18 years before treatment started. The researchers recruited 81 Swedish adolescents with severe obesity who underwent Roux-en-Y gastric bypass surgery between 2006 and 2009. Their average BMI before treatment was 45. As a control group, the authors recruited 80 adolescents with an average BMI of 42, who were given conventional lifestyle obesity management, including cognitive behavioural therapy and family therapy.

Data on psychiatric drugs dispensed and specialist treatment for mental and behavioural disorders before treatment and five years afterwards were retrieved from national registers with individual data. In addition, participants in the surgical group reported their mental health problems (such as self-esteem, mood, binge eating and other eating behaviours) using a series of questionnaires before surgery, and one, two and five years afterwards. The number of participants who completed questionnaires declined to 75 by year five.

Before treatment, the proportion of adolescents prescribed psychiatric drugs was similar in both groups and substantially higher than the proportion in the general population (20% in the surgical group and 15% in the control group, compared to 2% in the general population). Five years after surgery, the proportion of adolescents prescribed psychiatric drugs increased in both groups, and both groups also saw an increase in the proportion who received specialist mental health care. However, adolescents who had surgery went on to have significantly more hospital-based inpatient and outpatient care for mental health problems than those in the control group (36%, or 29 of 81 participants, compared to 21%, or 17 of 80). The authors explain that this does not necessarily mean that surgery exacerbates mental health problems. Instead, it could be that adolescents who undergo surgery are monitored more closely, and therefore get better access to mental health care.

Five years after treatment, self-reported measures of mental health improved slightly in the surgical group. Self-esteem improved from an average score of 19 pre-surgery (from a possible score of 0-30, with higher score indicating higher self-esteem) to a score of 22 at five years, while binge eating, emotional eating and uncontrolled eating were all reported less often.

Overall mood had not improved at the five-year follow-up. The average score was unchanged and 72% (54 of 75) of the adolescents and young adults questioned scored below the average of those of a similar age in the general population.

Overall mood had not improved at the five-year follow-up. The average score was unchanged and 72% (54 of 75) of the adolescents and young adults questioned scored below the average of those of a similar age in the general population.

The authors highlight several limitations to their study. For example, it was not randomised and there were not enough adolescents with the same degree of severe obesity to perfectly match the control and surgical groups. Adolescents in the surgical group had a slightly higher BMI before treatment and were slightly older, so psychosocial problems may have been more prevalent. The small sample size might have prevented the researchers from detecting other important differences between the groups.

Writing in a linked Comment, lead author Dr Stasia Hadjiyannakis (who was not involved in the study) from the University of Ottawa, Canada, says: "The high burden of mental health risk in youth with severe obesity needs to be better understood. Bariatric surgery does not seem to alleviate these risks, despite resulting in significant weight loss and other physical health benefits. Those living with obesity encounter weight bias and discrimination which in turn can negatively affect mental health. We must advocate for and support strategies aimed at decreasing weight bias and discrimination to begin to address mental health risk through upstream action."



This study was funded by the Swedish Research Council, VINNOVA, Västra Götalandsregionen, ALF VG-region, Region Stockholm, Swedish Child Diabetes Foundation, Swedish Heart and Lung Foundation, Tore Nilsson's Foundation, SUS Foundations and Donations, Capio Research Foundation, and Mary von Sydow's Foundation. It was conducted by researchers from Skåne University Hospital, the University of Gothenburg, the Karolinska Institute, the Finnish National Institute for Health and Welfare, Lund University, the Royal College of Surgeons of England, Sahlgrenska University Hospital, Örebro University, and Linköping University.

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[1] [2] Quote direct from author and cannot be found in the text of the Article.

Peer-reviewed / Observational study / People

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