News Release 

Study resurrects mammoth DNA to explore the cause of their extinction

Oxford University Press USA

A new study in Genome Biology and Evolution, published by Oxford University Press, resurrected the mutated genes of the last herd of woolly mammoths and found that their small population had developed a number of genetic defects that may have proved fatal for the species.

Woolly mammoths were one of the most abundant, cold-adapted species on earth before the conclusion of the Pleistocene (~11,700 years ago). The end of this period was marked by dramatic climate fluctuations that eventually gave way to Holocene - which saw the near complete loss of cold and dry steppe tundra, (also known as the Mammoth steppe). This change caused the extinction of many species, including cave bears, cave hyenas, the woolly rhinoceros, and the continental population of woolly mammoths.

An isolated population of mammoths disappeared later on St. Paul Island due to rising sea levels and a lack of freshwater, which left only a small population of woolly mammoths (~ 300-500) on Wrangel Island, a remote Arctic refuge off the coast of Siberia. This final herd of mammoths died out some 5,000 years ago, though the cause of their extinction has long been a mystery.

Researchers here built upon the prior scientific studies that identified potentially harmful genetic mutations on the Wrangel Island mammoths. Comparing the DNA of a Wrangel Island mammoth to that of 3 Asian elephants and 2 more ancient mammoths, the study found a number of unique genetic mutations. The genes that showed these mutations related to a range of important functions, including neurological development, male fertility, insulin signalling, and sense of smell.

The final cause of the extinction of the Wrangel Island mammoths is still a mystery, but it is clear that, due to a decline in their population, they suffered from a medley of genetic defects that may have hindered their development.

"We know how the genes responsible for our ability to detect scents work," says Vincent J. Lynch, an assistant professor of biological sciences at the University at Buffalo. "So we can resurrect the mammoth's version, make cells I culture produce the mammoth gene, and then test whether the protein functions normally in cells. If it doesn't - and it didn't - we can infer that it probably means that Wrangel Island mammoths were unable to smell the flowers that they ate."

###

The paper "Functional architecture of deleterious genetic variants in the genome of a Wrangel Island mammoth" is available at:

Direct correspondence to:
Vincent J. Lynch
Department of Biological Sciences
University at Buffalo - SUNY
551 Cooke Hall
Buffalo, NY
14260
vjlynch@buffalo.edu

To request a copy of the study, please contact: Timothy Thomas (timothy.thomas@oup.com)

Sharing on social media? Find Oxford Journals online at @OxfordJournals

DOI: 10.1093/gbe/evz279

Please acknowledge Genome Biology and Evolution as a source in any articles.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.