image: People with autism have less pupil dilation compared to controls while they are distracted, revealing dysregulated activity in the locus coeruleus. view more
Credit: Granovetter et al., JNeurosci 2020
New research in JNeurosci explores how a particular region of the brainstem might explain differences in attention in people with autism.
In day-to-day life, we are confronted with an abundance of information, and have to be able to selectively attend to the most relevant aspects of our environment. A region of the brainstem called the locus coeruleus is involved in controlling attention. Because people with autism spectrum disorder show differences in how they regulate their attention, Granovetter et al. explored how the locus coeruleus behaves in individuals with autism. Researchers had participants perform an attention-demanding task and monitored their pupil dilation, which provides information about locus coeruleus activity.
Adult participants watched letters flash on a screen and pushed a button if the same letter appeared twice in a row. They then repeated this task with a distraction -- auditory tones played at random times. All participants performed equally well on the task, but participants with autism had atypically smaller pupil dilations compared to controls during the more distracting condition, suggesting a dysregulation in locus coeruleus activity. This dysregulation might explain exaggerated responses to environmental stimuli as well as fixated behaviors and interests that characterize autism spectrum disorder.
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Manuscript title: Uncharacteristic Task-Evoked Pupillary Responses Implicate Atypical Locus Coeruleus Activity in Autism
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About JNeurosci
JNeurosci, the Society for Neuroscience's first journal, was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.
About The Society for Neuroscience
The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 37,000 members in more than 90 countries and over 130 chapters worldwide.