News Release 

The Lancet Infectious Diseases: Contact tracing and isolation key to controlling SARS-CoV2 in Shenzhen

The Lancet

Contact tracing to rapidly isolate people who could be infected with coronavirus disease 2019 (COVID-19) reduced the length of time people were infectious in the community over 4 weeks (from 14 January to 12 February 2020) in Shenzhen, China, according to results from 391 cases and 1,286 of their close contacts, published in The Lancet Infectious Diseases journal.

In Shenzhen, authorities identified who to isolate based on their contact with confirmed cases, as well as isolating people who already had symptoms. The new study finds that contact tracing increased the speed at which new cases were confirmed by 2 days (an average of 5.5 days initially, reduced to 3.2 with contact tracing). It also reduced the amount of time it took to isolate infected people by 2 days (from an average of 4.6 days down to 2.7). There were only three deaths in the study group during the study period.

On January 8, 2020, authorities began to monitor travellers from Hubei province for symptoms such as a fever and cough, and after 2 weeks expanded to monitor people without symptoms as well as the wider community. Suspected cases and their close contacts provided nasal swabs, which were tested for coronavirus at 28 local hospital and 12 other centres. People with symptoms were isolated and treated in hospital before their test results were known, and those without symptoms were quarantined at dedicated facilities. Close contacts who tested negative were quarantined at home or in a dedicated facility and monitored for 14 days.

During the study period, the reproductive number among observed cases was 0.4, far below the threshold of 1 required for incidence to decline. However, since this was only among traced contacts the true reproductive number was likely higher, though the end of the local outbreak suggests it also was below 1.

"The experience of COVID-19 in the city of Shenzhen may demonstrate the huge scale of testing and contact tracing that's needed to reduce the virus spreading," says Dr Ting Ma from the Harbin Institute of Technology at Shenzhen, China. "Some of the strict control measures enforced here, such as isolating people outside their homes, might be unlikely to be replicated elsewhere, but we urge governments to consider our findings in the global response to COVID-19. To achieve similar results, other countries might be able to combine near-universal testing and intensive contact tracing with social distancing and partial lockdowns. Although no lockdown measures were introduced in Shenzhen until the end of our study period, Wuhan's lockdown could have significantly restricted the spread of coronavirus to Shenzhen." [2]

For the current study, the authors analysed data from 391 people diagnosed with COVID-19 after they showed symptoms, and 1,286 of their close contacts. The contacts were tested irrespective of whether they had symptoms in order to identify infected people who were asymptomatic. The data gave insights into the type of contact most likely to lead to transmission. Close contacts were defined as people who shared a household with infected patients up to 2 days before they started showing symptoms, or interacted with them socially by travelling or eating together.

For people who were isolated because they showed symptoms of COVID-19, it took an average of 4.6 days for them to be isolated following the first signs of infection. Contact tracing reduced this to an average of 2.7 days. For people diagnosed with COVID-19 after being contact traced and tested (87 people), a fifth (17 out of 87 people) had not yet developed any symptoms, and 30% (25 out of 87) did not have a fever.

Contact tracing also reduced the length of time between someone first experiencing symptoms and being diagnosed. It took an average of 5.5 days if people were only tested after they reported symptoms, but with contact tracing there was only a delay of an average of 3.2 days between the first symptoms and a confirmed diagnosis.

The length of time for which a person remains infectious is not yet known, but reducing the amount of time that infected people interacted with others appears to have helped reduce the virus spreading.

In this study, transmission was most likely between people who shared a household, but not all close contacts caught COVID-19, with only 11% of close contacts of this kind developing the disease. Of close contacts who travelled together with an infected person (for example on a plane, bus, train or boat), an average of 6% developed the disease. Of close contacts who shared a meal with an infected person, an average of 9% developed the disease. The authors note that these transmission rates will be higher in other countries, where measures such as isolation outside the home might not be as strict or rapid. These data do not give any insights into why some cases cause higher levels of transmission than others.

The study also provided results on the likelihood of infection by age group, the severity of symptoms according to age group, the incubation period before symptoms began, and the recovery time or time to death. The results were consistent with those from previous studies.

The authors highlight several limitations to their study, including that it is impossible to trace every potential contact an individual has. Contact tracing therefore focuses on close contacts who are most likely to be infected. They note that some infected travellers to Shenzhen could have been missed if they were only tested due to symptoms such as a fever. Their contacts might also have been missed if they were asymptomatic, because the PCR test is not sensitive enough to pick up every case.

Writing in a linked Comment, lead epidemiologist Dr Cécile Viboud (who was not involved in the study) from the National Institutes of Health, USA, says: "As we look towards post-lockdown strategies, we should examine the experience of countries that have successfully controlled SARS-CoV-2 transmission or have low mortality (eg, China, Singapore, Taiwan, South Korea, Germany, and Iceland). Successful strategies include ample testing and contact tracing, supplemented by moderate forms of social distancing. Contact tracing on the scale that is needed for the SARS-CoV-2 response is labour intensive, and imperfect if done manually. Hence new technology-based approaches are greatly needed to assist in identification of contacts, especially if case detection is aggressive. Building on the SARS-CoV-2 experience in Shenzhen and other settings, we contend that enhanced case finding and contact tracing should be part of the long-term response to this pandemic--this can get us most of the way towards control."

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Peer-reviewed / Observational study / People

NOTES TO EDITORS

This study was funded by the Emergency Response Program of Harbin Institute of Technology, the Emergency Response Program of Peng Cheng Laboratory and the US Centers for Disease Control and Prevention. It was conducted by researchers from Johns Hopkins Bloomberg School of Public Health, Shenzhen Center for Disease Control and Prevention, Harbin Institute of Technology at Shenzhen, and Peng Cheng Laboratory, Shenzhen.

The labels have been added to this press release as part of a project run by the Academy of Medical Sciences seeking to improve the communication of evidence. For more information, please see: http://www.sciencemediacentre.org/wp-content/uploads/2018/01/AMS-press-release-labelling-system-GUIDANCE.pdf if you have any questions or feedback, please contact The Lancet press office pressoffice@lancet.com

[1] https://doi.org/10.1016/S1473-3099(20)30243-7

[2] Quote direct from author and cannot be found in the text of the Article.

For interviews with the Article author, please contact:

Dr Ting Ma: E) tma@hit.edu.cn T) +86-18825278961

Professor Justine Lessler: E) justin@jhu.edu T) 919-599-2133, or Communications Associate Jon Eichberger: T) je@jhu.edu

For interviews with the Comment author, please contact NIH Communications Director Ann Puderbaugh: E) puderba@mail.nih.gov

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