News Release 

New heart attack testing protocol expedites treatment in ER

UT Southwestern Medical Center

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IMAGE: Dr. Rebecca Vigen view more 

Credit: UTSW

DALLAS - April 22, 2020 - A new protocol using highly sensitive blood tests to determine whether someone is having a heart attack can reduce wait times and overcrowding in emergency departments, according to a new study from UT Southwestern Medical Center.

The findings, published online today in JAMA Open, are particularly meaningful during the current coronavirus pandemic when many people with chest pain may be fearful of going to the hospital.

"Patients are more reluctant to come to the ER with heart-related symptoms during the COVID-19 outbreak. We do not want those with medical emergencies to avoid the hospital due to concern for risk from the virus," says cardiologist Rebecca Vigen, M.D., assistant professor of internal medicine at UT Southwestern.

The research team led by Vigen found that a new protocol for using high sensitivity cardiac troponin testing can improve efficiency in the ER by more quickly determining which patients are not having a heart attack. Troponins are proteins released when the heart muscle has been damaged. The protocol incorporates the HEART score - history, electrocardiogram, age, risk factors, and troponin - an emergency department risk assessment tool that guides decisions on discharge and stress testing. 

According to the Centers for Disease Control and Prevention, chest pain is the most common reason for trips to the ER, resulting in 7 million annual visits. 

"Our innovative strategy allowed us to 'rule out' heart attacks within one hour in more than half of the patients who were tested. This process is safe and improves the efficiency of evaluating patients with possible heart attacks," says James de Lemos, M.D., professor of internal medicine at UT Southwestern and co-author of the study.

"Emergency room overcrowding has become an urgent health priority that is even more pressing in the current COVID-19 pandemic. Given the large size of the study and its performance during routine operations in our county hospital, we think the findings would apply to many busy U.S. emergency rooms," de Lemos adds. 

The new protocol was first implemented in December 2017 at Parkland Memorial Hospital, a major safety net hospital in Dallas, and then in October 2018 at UT  Southwestern's William P. Clements Jr. University Hospital. The study included 31,543 emergency room patients at Parkland from Jan. 1, 2017, to Oct. 16, 2018. Their mean age was 54, the population was racially and ethnically diverse, and 48 percent were women. 

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Other UTSW researchers who contributed to the study were Dergham Alzubaidy, Sandeep R. Das, Deborah B. Diercks, Ibrahim A. Hashim, Jose A. Joglar, Jeffery C. Metzger, Kyle Molberg, Ambarish Pandey, Jose Soto, and Lin Zhong. Contributing from Parkland Health and Hospital System: Bryan Bertulfo, Fernabelle Fernandez, Patricia Kutscher, Lorie Thibodeaux, and Amy Yu.

de Lemos, who holds the Sweetheart Ball-Kern Wildenthal, M.D., Ph.D. Distinguished Chair in Cardiology, receives grant support from Roche Diagnostics and Abbott Diagnostics and consulting income from Roche Diagnostics, Abbott Diagnostics, Ortho Clinical Diagnostics, and Endpoint Committees for Radiometer, Quidel Cardiovascular Inc., and Siemens Healthcare Diagnostics.

About UT Southwestern Medical Center

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty has received six Nobel Prizes, and includes 22 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 14 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,500 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in about 80 specialties to more than 105,000 hospitalized patients, nearly 370,000 emergency room cases, and oversee approximately 3 million outpatient visits a year.

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