July 23, 2020 - Although rates of surgery for Crohn's disease have decreased over the years, many patients still require surgical treatment - due to inadequate responses to medical therapy, severe attacks of acute colitis, and many other situations. Reflecting the latest research evidence and clinical practice, an updated set of recommendations for surgery in patients with Crohn's disease have been published in Diseases of the Colon & Rectum (DC&R), the official journal of the American Society of Colon and Rectal Surgeons (ASCRS). The journal is published by Wolters Kluwer.
Developed by the ASCRS Clinical Practice Guidelines Committee, the revised recommendations were posted today on the DC&R website and will appear in the journal's August issue. Amy L. Lightner, MD, of the Cleveland Clinic was lead author on behalf of the Committee. She comments, "We hope these guidelines will offer guidance in navigating the increasingly complex and multi-disciplinary management of Crohn's disease."
Surgery for Crohn's Disease: Indications and Considerations Before, During and After Surgery
"Crohn's disease is an idiopathic, incurable chronic inflammatory disease of the GI tract, which affects over one million people in the United States and continues to increase in incidence for unknown reasons," according to the guideline statement. With effective medical therapies, the need for surgical treatment of Crohn's disease, including emergency surgery, has decreased over the years.
Yet nearly half of patients still require surgery within five years after being diagnosed with Crohn's disease, and remain at high long-term risk of repeat surgery. The prior ASCRS Crohn's disease practice guidelines were published in 2015. The 2020 updated clinical practice guidelines reflect the research that has been published over the interval, including grades specific for each recommendation about how the new evidence may impact clinicians' practice. The 2020 guidelines consist of 28 recommendations, organized into five categories:
Operative Indications. Several recommendations address the varied indications for surgery in patients with Crohn's disease. Although most patients respond to anti-inflammatory therapies, including steroids and monoclonal antibodies, some develop "medically refractory" disease, requiring surgery due to inadequate response, complications, or other inability to tolerate medical treatment.
Other indications for surgery include severe colitis (inflammation of the colon) with "impending or actual" perforation; strictures (narrowing of the bowel) that cannot be treated with medications or endoscopy; "penetrating" disease such as perforations, abscesses, or fistulas; and hemorrhage (bleeding). The revised guidelines also include an expanded discussion of surgical treatment for patients with dysplasia (precancerous lesions) or cancer of the colon and rectum - a long-term complication of Crohn's disease.
Site-Specific Operations. The guidelines include an extensive discussion and recommendations for surgery at different sites along the gastrointestinal tract. In each situation, the Committee includes recommendations for the extent of surgery and the need for an ostomy. This section also includes recommendations for emergency surgery in patients with severe, acute Crohn's colitis.
Preoperative, Intraoperative, and Postoperative Considerations. The revised guidelines include three updated sections focusing on considerations before, during, and after surgery for patients with Crohn's disease. In the preoperative period, treatment with steroids should be discontinued if possible, due to the risk of infection. Other recommendations address the need for preoperative nutritional support and the importance of smoking cessation.
Intraoperative recommendations call for the use of minimally invasive surgical approaches, when possible. Key considerations of surgical technique are discussed, including new evidence on surgical advances. Postoperative considerations address the role of medical therapy to treat residual disease activity or maintain Crohn's disease in remission after surgery.
The Committee emphasizes that the management of patients with Crohn's disease involves different medical disciplines working in conjunction together; as such, the guidelines "represent only a portion of the treatment necessary for the optimal care of these patients." Dr. Lightner adds: "Given the ever-evolving management options for patients with Crohn's Disease, this guideline provides an up-to-date summary of current management."
About Diseases of the Colon & Rectum
Diseases of the Colon & Rectum is the world's leading publication in colorectal surgery, ranking in the top 13% of all peer-reviewed surgery journals. DC&R is the recognized authority on conditions affecting the colon, rectum, and anus, publishing original articles, reviews, and short communications. For more than 50 years, DC&R has been the journal of choice among colorectal surgeons and gastroenterologists for the transfer of both medical and surgical knowledge and information in this highly specialized field.
About the American Society of Colon and Rectal Surgeons
The American Society of Colon and Rectal Surgeons (ASCRS) is the premier society for colon and rectal surgeons and other healthcare providers dedicated to advancing and promoting the science and practice of the treatment of patients with diseases and disorders affecting the colon, rectum and anus. More than 1,000 of the Society's 3,500 members are certified by the American Board of Colon and Rectal Surgery. We believe in patient-centered, high-quality, high-value health care. We achieve this care through professionalism, unique knowledge and skills, and the fellowship of the Society's members.
About Wolters Kluwer
Wolters Kluwer (WKL) is a global leader in professional information, software solutions, and services for the clinicians, nurses, accountants, lawyers, and tax, finance, audit, risk, compliance, and regulatory sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with advanced technology and services.
Wolters Kluwer reported 2019 annual revenues of €4.6 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries, and employs approximately 19,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands.
Wolters Kluwer provides trusted clinical technology and evidence-based solutions that engage clinicians, patients, researchers and students with advanced clinical decision support, learning and research and clinical intelligence. For more information about our solutions, visit https:/