The primary goal of this study by Amanda H. Anderson et al was to identify independent risk factors of CKD progression among participants with and without diabetes in a prospective CKD cohort study (N=3,379). Among those with diabetes, CKD progression rates approximately doubled with higher levels of the inflammatory chemokine CXCL12, the cardiac marker NTproBNP and the kidney injury marker urine NGAL. Among those without diabetes, rates increased over 1.5-fold with higher levels of high-sensitivity troponin T, NTproBNP, and urine NGAL. The strength of these associations exceeded that of systolic blood pressure ≥140 mmHg, a well-established risk factor for kidney disease progression. These findings provide insights into potential mechanisms of CKD progression and will guide future research in defining subgroups at highest risk for CKD progression.
Title: Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Authors: Amanda H. Anderson, Dawei Xie, Xue Wang, Robin L. Baudier, Paula Orlandi, Lawrence J. Appel, Laura M. Dember, Jiang He, John W. Kusek, James P. Lash, Sankar D. Navaneethan, Akinlolu Ojo, Mahboob Rahman, Jason Roy, Julia J. Scialla, James H. Sondheimer, Susan P. Steigerwalt, F. Perry Wilson, Myles Wolf, and Harold I. Feldman, on behalf of the CRIC Study Investigators