Oesophageal cancer is the eighth most common cancer worldwide. It often develops from a condition called Barrett's oesophagus. Existing monitoring and treatment methods are very intrusive, and many patients have to undergo burdensome procedures to ensure that no cancer is missed.
Researchers have now developed a statistical model that uses genomic data to accurately predict whether a patient with Barrett's oesophagus has a high or low risk of developing cancer.
Genomics and statistics come together
Researchers at the University of Cambridge, EMBL's European Bioinformatics Institute (EMBL-EBI), and collaborators sequenced genomes from biopsies routinely collected from patients with Barrett's oesophagus. These patients are monitored for early signs of oesophageal cancer. The researchers used the data to look for differences between patients who were ultimately diagnosed with cancer and those who were not. The data were used to develop a statistical model measuring each patient's individual risk. The research was published in Nature Medicine.
Other recent cancer studies have shown that genomic mutations leading to cancer may occur many years before a patient is diagnosed with the disease. Being able to identify these mutations could provide a new route to early diagnosis and treatment.
Using genomic data from 88 patients with Barrett's oesophagus, the researchers identified half of the patients who were diagnosed with oesophageal cancer as 'high risk' more than eight years before diagnosis. The numbers went up to 70% two years before diagnosis. Equally important, the model also accurately predicted patients who were at a very low risk of developing cancer.
"One of the unique things about this study was the richness of the data provided by colleagues at Addenbrooke's Hospital in Cambridge," explains Moritz Gerstung, Group Leader at EMBL-EBI. "These patients have been in surveillance for over 15 years, so overall we had over 800 samples, taken over time and from different areas of the oesophagus. This allowed us to measure in great detail what type of genomic changes occur and how these trajectories differ between patients with and without cancer. Without such thorough surveillance programmes, this study wouldn't have been possible."
The benefit of early detection
Although people with Barrett's oesophagus are at considerably higher risk of developing oesophageal cancer than the general population, only 1 patient in 300 will be diagnosed with cancer per year. Nevertheless, they all have to go through intrusive monitoring procedures every two years. This surveillance can be uncomfortable, stressful, and time-consuming for the patients, and it places an additional burden on the healthcare system.
"The benefit of our method is twofold," explains Sarah Killcoyne, Visiting Postdoctoral Fellow at EMBL-EBI. "The patients who have high-risk Barrett's, which is likely to become cancerous, can receive treatment earlier. And individuals who have something that looks genetically stable, and unlikely to develop into the disease, do not need to undergo such intense surveillance. The hope is that our method can help improve early detection and treatment, and decrease unnecessary treatment for low-risk patients, without compromising patient safety."
These results mean that patients at greatest risk can be treated immediately, rather than conducting repeated biopsies until early signs of cancer are found. Conversely, patients with low risk and stable disease can be monitored less frequently. Overall, the authors estimate that monitoring can be reduced for 50% of patients with Barrett's oesophagus.
"This is an exciting example of how a collaboration between computational biologists and clinician scientists can bring new insights into an important clinical problem," says Rebecca Fitzgerald, Professor of Cancer Prevention and MRC Programme Leader at the University of Cambridge. "Oesophageal cancer is devastating when it is diagnosed late, but early intervention can be performed endoscopically and spare patients unnecessary chemotherapy and removal of their oesophagus. Similar approaches could be extended to other cancer types in the future."
According to the authors, the next steps are to refine the method, ideally by analysing data from more patients. It is also important to bring in clinical information and improve the model's accuracy. Eventually, this will lead to clinical trials to show that this model is useful in clinical practice for patients currently in surveillance.
KILLCOYNE, S., et al. (2020). Genomic copy number predicts oesophageal cancer years before transformation. Nature Medicine. Published online 07 09; DOI: 10.1038/s41591-020-1033-y
European Bioinformatics Institute (EMBL-EBI)
The European Bioinformatics Institute (EMBL-EBI) is a global leader in the storage, analysis and dissemination of large biological datasets. We help scientists realise the potential of 'big data' by enhancing their ability to exploit complex information to make discoveries that benefit humankind.
We are at the forefront of computational biology research, with work spanning sequence analysis methods, multi-dimensional statistical analysis and data-driven biological discovery, from plant biology to mammalian development and disease.
We are part of EMBL and are located on the Wellcome Genome Campus, one of the world's largest concentrations of scientific and technical expertise in genomics.
University of Cambridge
The mission of the University of Cambridge is to contribute to society through the pursuit of education, learning and research at the highest international levels of excellence. To date, 109 affiliates of the University have won the Nobel Prize.
Founded in 1209, the University comprises 31 autonomous Colleges and 150 departments, faculties and institutions. Cambridge is a global university. Its 19,000 student body includes 3,700 international students from 120 countries. Cambridge researchers collaborate with colleagues worldwide, and the University has established larger-scale partnerships in Asia, Africa and America.
The University sits at the heart of the 'Cambridge cluster', which employs more than 61,000 people and has in excess of £15 billion in turnover generated annually by the 5,000 knowledge-intensive firms in and around the city. The city publishes 316 patents per 100,000 residents.
National Institute for Health ResearchThe National Institute for Health Research (NIHR) is the nation's largest funder of health and care research. The NIHR:
- Funds, supports and delivers high quality research that benefits the NHS, public health and social care
- Engages and involves patients, carers and the public in order to improve the reach, quality and impact of research
- Attracts, trains and supports the best researchers to tackle the complex health and care challenges of the future
- Invests in world-class infrastructure and a skilled delivery workforce to translate discoveries into improved treatments and services
- Partners with other public funders, charities and industry to maximise the value of research to patients and the economy
The NIHR was established in 2006 to improve the health and wealth of the nation through research, and is funded by the Department of Health and Social Care. In addition to its national role, the NIHR supports applied health research for the direct and primary benefit of people in low- and middle-income countries, using UK aid from the UK government.
This work uses data provided by patients and collected by the NHS as part of their care and support and would not have been possible without access to this data. The NIHR recognises and values the role of patient data, securely accessed and stored, both in underpinning and leading to improvements in research and care. http://www.