New research from the International Collaboration on Repair Discoveries (ICORD) challenges the current standard for managing blood pressure in people with spinal cord injury (SCI).
The findings, published today in Nature Communications, could lead to a change in the way newly injured patients have their blood pressure managed, potentially improving their chances of retaining more function in the long term.
This study, led by ICORD principal investigators Dr. Christopher West and Dr. Brian Kwon, demonstrated that following high-thoracic SCI, the heart's ability to contract is impaired, leading to reduced spinal cord blood flow. High-thoracic SCI generally refers to injuries that affect the abdominal and lower back muscles and the legs, typically resulting in paraplegia, while arm and hand function may not be affected.
Currently, a patient being treated for acute SCI--a traumatic injury that bruises, partially or fully tears the spinal cord--has their blood pressure managed using drugs that cause their blood vessels to constrict in order to increase blood pressure.
In this study, the research team tested an experimental treatment targeting the heart to beat more powerfully, which increased the amount of blood ejected and also increased blood pressure.
"The key difference is that by targeting the heart, we increase blood pressure by increasing blood flow instead of by causing the blood vessels to narrow," said West. "This is important because by increasing blood flow we can deliver more blood and oxygen to the spinal cord which is expected to minimize the damage at the epicentre of the injury, and therefore reduce injury severity and bleeding in the cord, both of which are expected to improve the chances of people with SCI retaining more function."
This could mean in the future that an individual who is newly admitted to the hospital may receive a different drug during their initial period of post-injury management. If proven to be effective in humans with SCI, it could improve their chances of retaining more function in the long-term.
"It is important to point out that one of the only things we can currently do for acute SCI patients is to try to optimize the supply of blood and oxygen to the injured spinal cord to prevent further secondary injury," said Kwon. "We need to seek ways of delivering this care in the most effective manner possible, as any bit of spinal cord function that could be improved upon by novel approaches such as this would potentially be very impactful to a patient."
ICORD is supported by the University of British Columbia's faculty of medicine and the Vancouver Coastal Health Research Institute.