News Release 

Randomized trial of laparoscopic, open liver surgery found no difference in long-term survival ou

Embargoed news from Annals of Internal Medicine

American College of Physicians

Research News

Embargoed for release until 5:00 p.m. ET on Monday 16 November 2020

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Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.

1. Randomized trial of laparoscopic and open liver surgery found no difference in long-term survival outcomes between treatment groups

A previously published study showed short-term surgery-related benefits to a laparoscopic approach

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A randomized trial of laparoscopic and open liver surgery for patients with metastatic colon cancer found no difference in survival outcomes between treatment groups. Previously published short-term results showed that the laparoscopic approach led to fewer complications within 30 days after surgery, faster recovery, and shorter hospital stays. Findings from a randomized, controlled trial are published in Annals of Internal Medicine.

Most patients with metastatic colon or rectal cancer cannot be cured. However, a subset of such patients with isolated liver metastasis can have surgical removal, or resection, of the metastatic tumor in the liver, which might cure their disease. Patients may have traditional open surgery, or a minimally-invasive laparoscopic approach. However, no high-level evidence supports the oncological safety of laparoscopic liver resection.

Researchers from Oslo University Hospital in Norway studied 280 patients with resectable colorectal liver metastases to compare open versus laparoscopic surgical approaches with respect to 5-year survival outcomes. This is the first randomized controlled trial comparing the two approaches and short-term results of this trial were already published. The patients were randomly assigned to have either laparoscopic surgery or open surgery and the researchers compared survival without cancer recurrence at 5 years between the two groups. They found no difference in survival between the laparoscopic and open approaches. The researchers suggest that since the laparoscopic approach does not jeopardize oncologic outcomes and may provide better short-term outcomes when applied in ideal conditions, both surgical options should be discussed with appropriate patients.

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