Philadelphia, December 7, 2020--Despite early reports suggesting a decline in preterm births during the COVID-19 pandemic period, an analysis by researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania has found no change in preterm births or stillbirths at two Philadelphia hospitals in the first four months of the pandemic. The findings, published today in JAMA, resulted from the examination of an ongoing, racially-diverse pregnancy cohort that assesses both spontaneous and medically-indicated preterm birth.
"Preterm birth is highly complex, with a diverse set of presentations and unknown causes," said Heather H. Burris, MD, MPH, an attending physician in CHOP's Division of Neonatology and senior author of the study. "Because we have two independent reviewers assessing every preterm birth at two Penn Medicine hospitals, we were able to complete a rigorous analysis of multiple types of preterm birth for the first four months of the pandemic and compare that data to the same period in previous years."
The cohort, known as GeoBirth, includes more than 100,000 births at two Penn Medicine hospitals in Philadelphia since 2008. Each preterm birth, characterized as any birth occurring before 37 weeks' gestation, is manually classified by two independent, blinded reviewers as either a spontaneous preterm birth or a medically-indicated preterm birth. The former includes preterm labor or early rupture of the membranes, and the latter includes conditions that necessitate an early delivery for the health of the mother or baby, such as preeclampsia or intrauterine growth restriction.
The researchers analyzed 2,992 live births from March through the end of June 2020 and compared those births to 5,875 over the same four-month period in 2018 and 2019. Making use of the robust GeoBirth data set, the research team compared rates of overall preterm birth, spontaneous preterm birth, medically-indicated preterm birth, and stillbirth, defined as intrauterine demise after 20 weeks.
The data did not show any significant change in preterm or stillbirth rates during the COVID-19 pandemic. Even when breaking down the preterm birth data by spontaneous and medically-indicated preterm births, the researchers still did not detect differences between the pre-pandemic and pandemic period. These findings differ from European studies that have reported a decrease in preterm birth and increase in stillbirth during the first few months of the pandemic.
"While particular mechanisms that lead to preterm birth remain elusive, we know that various individual and environmental factors are linked to poor birth outcomes, and that those factors vary by demographic groups. Our years of work in this field led us to question other reports that suggested preterm births and stillbirths had decreased across the board over this extremely stressful and uncertain pandemic period," said Michal Elovitz, MD, director of the Maternal and Child Research Center and the Hilarie L. Morgan and Mitchell L Morgan President's Distinguished Professor in Women's Health at Penn. "The power of the GeoBirth cohort will allow us with the opportunity to query how individual, societal and environmental factors affect pregnant women and how those factors may be heightened by all the varying effects of a pandemic. It is imperative that we have rigorous tools to study how these different factors may harm pregnant people and how the pandemic may exacerbate those factors so we can target appropriate strategies to improve the lives of women and their babies."
Handley et al. "Changes in preterm birth phenotypes and stillbirth at two Philadelphia hospitals during the SARS-CoV-2 pandemic from March-June 2020," JAMA, online December 7, 2020, DOI: 10.1001/jama.2020.20991
About Children's Hospital of Philadelphia: Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. In addition, its unique family-centered care and public service programs have brought the 595-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.
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Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $8.6 billion enterprise.
The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $494 million awarded in the 2019 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center--which are recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report--Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nation's first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.
Penn Medicine is powered by a talented and dedicated workforce of more than 43,900 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2019, Penn Medicine provided more than $583 million to benefit our community.