Wielding a laser beam deep inside the body

(Boston) -- Minimally invasive surgeries in which surgeons gain access to internal tissues through natural orifices or small external excisions are common practice in medicine. They are performed for problems as diverse as delivering stents through catheters, treating abdominal complications, and performing transnasal operations at the skull base in patients with neurological conditions.

The ends of devices for such surgeries are highly flexible (or "articulated") to enable the visualization and specific manipulation of the surgical site in the target tissue. In the case of energy-delivering devices that allow surgeons to cut or dry (desiccate) tissues, and stop internal bleeds (coagulate) deep inside the body, a heat-generating energy source is added to the end of the device. However, presently available energy sources delivered via a fiber or electrode, such as radio frequency currents, have to be brought close to the target site, which limits surgical precision and can cause unwanted burns in adjacent tissue sections and smoke development.

Laser technology, which already is widely used in a number of external surgeries, such as those performed in the eye or skin, would be an attractive solution. For internal surgeries, the laser beam needs to be precisely steered, positioned and quickly repositioned at the distal end of an endoscope, which cannot be accomplished with the currently available relatively bulky technology.

Now, robotic engineers led by Wyss Associate Faculty member Robert Wood, Ph.D., and postdoctoral fellow Peter York, Ph.D., at Harvard University's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School for Engineering and Applied Science (SEAS) have developed a laser-steering microrobot in a miniaturized 6x16 millimeter package that operates with high speed and precision, and can be integrated with existing endoscopic tools. Their approach, reported in Science Robotics, could help significantly enhance the capabilities of numerous minimally invasive surgeries.

"To enable minimally invasive laser surgery inside the body, we devised a microrobotic approach that allows us to precisely direct a laser beam at small target sites in complex patterns within an anatomical area of interest," said York, the first and corresponding author on the study and a postdoctoral fellow on Wood's microrobotics team. "With its large range of articulation, minimal footprint, and fast and precise action, this laser-steering end-effector has great potential to enhance surgical capabilities simply by being added to existing endoscopic devices in a plug-and-play fashion."

The team needed to overcome the basic challenges in design, actuation, and microfabrication of the optical steering mechanism that enables tight control over the laser beam after it has exited from an optical fiber. These challenges, along with the need for speed and precision, were exacerbated by the size constraints - the entire mechanism had to be housed in a cylindrical structure with roughly the diameter of a drinking straw to be useful for endoscopic procedures.

"We found that for steering and re-directing the laser beam, a configuration of three small mirrors that can rapidly rotate with respect to one another in a small 'galvanometer' design provided a sweet spot for our miniaturization effort," said second author Rut Peña, a mechanical engineer with micro-manufacturing expertise in Wood's group. "To get there, we leveraged methods from our microfabrication arsenal in which modular components are laminated step-wise onto a superstructure on the millimeter scale - a highly effective fabrication process when it comes to iterating on designs quickly in search of an optimum, and delivering a robust strategy for mass-manufacturing a successful product."

The team demonstrated that their laser-steering end-effector, miniaturized to a cylinder measuring merely 6 mm in diameter and 16 mm in length, was able to map out and follow complex trajectories in which multiple laser ablations could be performed with high speed, over a large range, and be repeated with high accuracy.

To further show that the device, when attached to the end of a common colonoscope, could be applied to a life-like endoscopic task, York and Peña, advised by Wyss Clinical Fellow Daniel Kent, M.D., successfully simulated the resection of polyps by navigating their device via tele-operation in a benchtop phantom tissue made of rubber. Kent also is a resident physician in general surgery at the Beth Israel Deaconess Medical Center.

"In this multi-disciplinary approach, we managed to harness our ability to rapidly prototype complex microrobotic mechanisms that we have developed over the past decade to provide clinicians with a non-disruptive solution that could allow them to advance the possibilities of minimally invasive surgeries in the human body with life-altering or potentially life-saving impact," said senior author Wood, Ph.D., who also is the Charles River Professor of Engineering and Applied Sciences at SEAS.

Wood's microrobotics team together with technology translation experts at the Wyss Institute have patented their approach and are now further de-risking their medical technology (MedTech) as an add-on for surgical endoscopes.

"The Wyss Institute's focus on microrobotic devices and this new laser-steering device developed by Robert Wood's team working across disciplines with clinicians and experts in translation will hopefully revolutionize how minimally invasive surgical procedures are carried out in a number of disease areas," said Wyss Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at SEAS.

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The study was funded by the National Science Foundation under award #CMMI-1830291, and the Wyss Institute for Biologically Inspired Engineering.

PRESS CONTACT

Wyss Institute for Biologically Inspired Engineering at Harvard University Benjamin Boettner, benjamin.boettner@wyss.harvard.edu, +1 617-432-8232

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The Wyss Institute for Biologically Inspired Engineering at Harvard University uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing that are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and formation of new startups. The Wyss Institute creates transformative technological breakthroughs by engaging in high risk research, and crosses disciplinary and institutional barriers, working as an alliance that includes Harvard's Schools of Medicine, Engineering, Arts & Sciences and Design, and in partnership with Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Boston Children's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Boston University, Tufts University, Charité - Universitätsmedizin Berlin, University of Zurich and Massachusetts Institute of Technology.

The Harvard John A. Paulson School of Engineering and Applied Sciences serves as the connector and integrator of Harvard's teaching and research efforts in engineering, applied sciences, and technology. Through collaboration with researchers from all parts of Harvard, other universities, and corporate and foundational partners, we bring discovery and innovation directly to bear on improving human life and society.

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