Sophia Antipolis, 12 February 2021: The number of patients with heart failure worldwide nearly doubled from 33.5 million in 1990 to 64.3 million in 2017. That's the finding of a study published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1
"Our study challenges the common view that heart disease is fully under control," said study author Dr. Nicola Bragazzi of York University, Toronto, Canada.2 "Despite progress and achievements, the global burden imposed by heart failure is significantly growing."
The analysis used data from the Global Burden of Disease Study to examine the burden and causes of heart failure from 1990 to 2017 in 195 countries and territories. The age-standardised prevalence rate showed a slow downward trend, suggesting that population ageing and growth are responsible for most of the increase in prevalence.
The study revealed major differences between regions of the world. The researchers used the socio-demographic index (SDI) to categorise the 195 countries and territories into five groups according to development status: low, low-middle, middle, high-middle, and high SDI. Between 1990 and 2017, the age-standardised prevalence rate of heart failure decreased by 20.3% in high SDI countries but increased in the low, low-middle, and middle SDI countries.
The authors said the rising prevalence rate of heart failure in the low, low-middle, and middle SDI countries "is driven by a surge of risk factors such as hypertension, diabetes mellitus, obesity, smoking, and other unhealthy lifestyles".
Nearly half of the global increase in the number of heart failure patients during 1990 to 2017 was in China (29.9%) and India (16.6%). Dr. Bragazzi said: "An interplay of factors such as population growth, unhealthy behaviours including smoking, and air pollution are likely explanations."
The symptoms of heart failure can be debilitating. Shortness of breath, fatigue and fluid retention may limit patients' ability to walk, stand, work or care for themselves. The study found that years lived with disability due to heart failure have doubled worldwide since 1900, while the age-standardised rate remained stable.
There were stark differences in disability according to SDI category. A large decline in the age-standardised rate of years lived with disability was observed in high SDI countries - which the authors attributed to better prevention and treatment of heart failure. After an initial rise in high-middle and middle SDI countries, rates began to decline in 2010. But the rate continually deteriorated in low and low-middle SDI countries.
The authors said: "In low- and middle-income countries, the compliance to healthy lifestyle behaviours including healthy diets, physical activity and smoking cessation was rather poor." They added that four basic cardiovascular medicines (aspirin, beta-blockers, angiotensin-converting enzyme inhibitors, and statins) were generally unavailable or unaffordable for many populations in low and middle-income countries. "More targeted strategies aimed to modify multiple risk factors and improve the availability and affordability of medical care for heart failure are urgently needed for these countries," said the authors.
Ischaemic heart disease, hypertensive heart disease, and chronic obstructive pulmonary disease (COPD) were the top three causes of heart failure, accounting for nearly three-quarters of the age-standardised prevalence rates. There were regional differences - for example, COPD was a major cause of heart failure in South Asia and East Asia, where smoking and air pollution are contributors.
Dr. Bragazzi said: "Heart failure is a global public health concern. Public health workers and policymakers can use the data provided in this study to design interventions to prevent and manage heart failure in their countries. In addition, educational campaigns are needed to increase awareness about the importance of adopting healthy lifestyles."
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Funding: The GBD 2017 study was funded by the Bill and Melinda Gates Foundation. The present study was also funded by the National Natural Science Foundation of China (81974090) and Hospital Pharmacy Research Fund of Guangdong (2019YX18). However, the funders were not involved in any way in the preparation of this manuscript.
Disclosures: none declared.
1Bragazzi NL, Zhong W, Shu J, et al. Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017. Eur J Prev Cardiol. 2021. doi:10.1093/eurjpc/zwaa147.
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2Dr. Bragazzi is also affiliated with the University of Genoa, Italy, and the Department of General Medicine, Xiangya Hospital, Central South University, Changsha, China.
About the European Society of Cardiology
The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.
About theEuropean Journal of Preventive Cardiology
The European Journal of Preventive Cardiology is the world's leading preventive cardiology journal, playing a pivotal role in reducing the global burden of cardiovascular disease.