Tuberculosis is a serious infectious disease, which is caused by the Mycobacterium tuberculosis, generally it affects the lungs. Tuberculosis is spread from one person to another through microscopic droplets released into the air, it can happen through coughs, speaks, sneezes, spits, laughs from the active tuberculosis patient. According to the recent survey on tuberculosis by world Health Organization, in 2018, 10 million people fell ill with TB, and 1.5 million died from the disease. These numbers are alarming the need for more efforts to fight against the tuberculosis.
The book entitled "In-Silico and In-Vitro Approaches to Screen the Anti-tuberculosis Activity of Benzothiazole Analogs" comprises of six chapters, with extensive literature documentation on the benzothiazole analogs and corresponding structure activity relations, further authors enumerated the in-vitro and in-silico methodology for the screening the benzothiazole molecules to the anti-TB regime. Further various chapters explained the synthesis of the different types of the benzothiazole scaffold moiety and their tuberculosis activities with neat descriptions of the methodology. Additionally, each chapter includes the synthetic schemes, with mechanism for the benzothiazole derivatives.
This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.
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About the Author:
Dr. Mahesh Bhat obtained a Ph.D. from the University of Mysore, India. He completed a B.Sc. degree from Poorna Prajna College, Udupi. He successfully completed his Master's degree in Applied Chemistry from the Department of Chemistry, Mangalore University, Mangalore. He studied Organic, Inorganic, Physical, and Analytical Chemistry and carried out M.Sc. dissertation work at Kores India Limited, Maharashtra. Dr. Mahesh Bhat worked on the topic "Synthesis characterization and biological activity studies on Benzothiazole Derivatives." He synthesized many compounds that testify to his potential in the synthetic field. He has good research publications in reputed journals of international acclaim with good impact factors (Around 30 publications). Currently, he is working as an assistant professor in JSS College for Women, Saraswathipuram, Mysuru.
S.L. Belagali is a Ph.D. degree from Southampton University, U.K, in 1992 with the research work on natural products synthesis & biological activity evaluation. In 1986, he joined Mangalore University and became the reader in 1995 at the Chemistry department. In October 1999, he joined as a professor & co-coordinator of the Environmental Science department at the Mysore University and also worked as a chairman of the Environmental Science department. He was also a registrar (Administration) at Rani Channamma University, Belagavi, for 15 months. He has guided 20 students for the doctoral degree and four students for the M.Phil degree. On his credential, there are more than 150 publications in national and international reputed journals.
Keywords:
Tuberculosis, benzothiazole, anti-TB drugs, drug design, drug efficacy, Mycobacterium tuberculosis, treatment regimens
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