To date, muscle function, and in particular that of the lower extremity, in OI type IV has not been investigated systematically. This study now assesses upper and lower extremity muscle function finding that lower limb weakness may contribute to limitations in mobility in people with OI Type IV despite multidisciplinary treatment.
While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells.
As part of the Helmholtz Russia Research Group LaBeglo, UFZ researchers are studying the impact of climate change and environmental toxins on the lake's fauna. In a recent study, together with researchers from the Helmholtz Centre for Polar and Marine Research (AWI) and the University of Irkutsk, they addressed the question of how Baikal amphipods that fulfil important ecological functions in the lake react to pollutants in the water.
Inside the crater of a volcano on Graciosa Island in the Azores archipelago, in the Atlantic Ocean, an international team of researchers has discovered the bones of a new extinct species of songbird, a bullfinch which they have named Pyrrhula crassa. The remains were found in a small cavity through which time ago the lava flowed. This bird disappeared a few hundreds of years ago due to human colonization of the islands and the introduction of invasive species.
In preclinical experiments, researchers at VCU Massey Cancer Center have uncovered a new way in which colon cancer develops, as well as a potential 'silver bullet' for preventing and treating it. The findings may extend to ovarian, breast, lung, prostate and potentially other cancers that depend on the same mechanism for growth.
Bacterial populations can, under certain conditions, react in a coordinated manner to chemical messages produced by a minority of their members, as a new theoretical study carried out by LMU biophysicists shows.
Two studies examine the personality characteristics that drive dogmatism in the religious and nonreligious. In both groups, higher critical reasoning skills were associated with lower levels of dogmatism. But these two groups diverge in how moral concern influences their dogmatic thinking.
A new study assessed the safety, tolerability, and effectiveness of extended-release guanfacine in children 6-17 years of age who have chronic tic disorders including Tourette's disorder.
A novel combination of nivolumab plus ipilimumab for patients with metastatic kidney cancer is proving to be a more effective treatment with more durable tumor response than the two immunotherapies used separately. The promising combination therapy demonstrated manageable safety, notable antitumor activity, and durable responses with better long term overall survival in patients with metastatic renal cell cancer.
Despite the millions companies spend to gather information about customer satisfaction, senior managers often fail to understand those customers' expectations.