Researchers from the Salk Institute have shown that astrocytes -- long-overlooked supportive cells in the brain -- help to enable the brain's plasticity, a new role for astrocytes that was not previously known. The findings could point to ways to restore connections that have been lost due to aging or trauma.
Viral vectors used to deliver gene therapies undergo spontaneous changes during manufacturing which affects their structure and function. As gene therapy approaches become more common for treating disease, managing consistency of the molecular makeup of the virus particles that deliver genes is a key concern in manufacturing on a larger scale.
Diversifying working lands -- including farmland, rangeland and forests -- may be key to preserving biodiversity in the face of climate change, says a new review paper published this week in Science by biologists at the University of California, Berkeley. These changes could extend the habitat of critters like bats, but also much larger creatures like bears, elk and other wildlife, outside the boundaries of protected areas, while creating more sustainable, and potentially more productive, working lands.
Bacteria and Archaea have developed many types of CRISPR-Cas systems to protect themselves from viruses. A search through metagenomic databases of microbes, many of them uncultivatable, unearthed the genes of the smallest known working Cas complex, Cas14, from the genome of a DPANN Archaea, a group of microbes with the smallest known geomes. Cas14 is being incorporated into a CRISPR diagnostic called DETECTR.
Providing nurse-led care for people suffering with the painful, long-term condition gout could lead to an increase in the number of patients sticking to a beneficial treatment plan, a clinical trial has revealed.
A team of scientists led by Professor Richard Layfield at the University of Sussex has published breakthrough research in molecule-based magnetic information storage materials.
An international collaboration led by scientists at Yale has cracked a tough nut in multiple sclerosis: where are all the genes?
'Primary health care is in crisis... Leadership after the Astana meeting is essential to rejuvenate and revitalise all aspects of primary health care.' -- The Lancet special issue on primary health care marks 40 years since landmark Alma-Ata Declaration.
A new molecular engineering technique has the potential to double the number of light-sensitive proteins available for studying brain circuits.
Gout is the most common form of inflammatory arthritis, caused by crystallization of uric acid in the joint. Rheumatologists have long recommended that patients with gout be treated with drugs to lower uric acid in their blood to prevent crystallization. Specifically, rheumatology societies around the world recommend that uric acid should be lowered to below 6mg/dL because that's below the concentration at which uric acid can crystallize. This strategy is known as 'treat-to-target.'