An international team of researchers led by Keiji Tanimoto found how cancer cells respond to DNA damage signaling when in low oxygen, or hypoxia. Through comprehensive gene expression analyses, the team determined how one family of genes controls DNA damage response, as well as how they weaken the effectiveness of anticancer therapies.
Researchers from Yale-NUS College and the North Carolina Museum of Natural Sciences have discovered five new species of Southeast Asian frogs from a group of museum specimens that was believed to only contain two species. To distinguish the five new species from the original two, they examined almost 400 frogs from 11 natural history museum collections and sequenced five genes from close to 350 individuals. The research was recently published in the PLOS ONE.
Using animal models for researching type 2 diabetes mellitus (T2DM) impedes scientific breakthroughs about the disease origins and treatment options. Researchers recently proposed a human-centered research framework to study the biology of sugar metabolism in humans from molecules to population studies by utilizing novel human-based research technologies such as organ-on-chips and computer simulations.
A technique for growing sticky films of bacteria into elaborate microscopic images could reveal how potentially dangerous biofilms grow and transmit antibiotic resistance, and could lead to novel biomaterials or synthetic microbial communities.
A Norwegian biotech company called Phoenix Solutions AS is working with the Translational Genomics Research Institute (TGen), a Phoenix, Arizona-based biomedical research facility, to test the use of these pulsed sound waves to direct and focus cancer drug therapies.
Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease.
Three tumor samples collected over time from a single patient shows how cancer evolves in response to treatment: A higher percentage of cancer stem cells in the final sample make a more aggressive disease.
Jonathon Schuldt, assistant professor of communication at Cornell University, says it is possible to make faraway climate impacts feel closer. But that doesn't automatically inspire the American public to express greater support for policies that address it. The paper appeared in the Journal of Environmental Psychology.
Researchers have identified a therapeutic target to prevent or delay heart failure from pressure overload of the heart, and a potential biomarker for the same. They say their animal studies carry clinical and translational potential. Mouse-model experiments showed that preventing the early infiltration of CCR2+ macrophages into the heart, after experimental pressure overload, significantly lessened the heart's enlargement and reduced pumping ability that leads to later heart failure.
In January 2017 guidelines were released urging parents to begin early introduction of peanut-containing foods to reduce the risk of peanut allergy. A new study shows those who are aware of the guidelines are still hesitant to put them into place and not everyone has heard of them.