TB cAMP Receptor Protein (On State) (IMAGE)

National Institute of Standards and Technology (NIST)

TB cAMP Receptor Protein (On State)

Caption

This is a computer model of the predicted structure for the cyclic AMP receptor protein (CRP) found in Mycobacterium tuberculosis. After binding cyclic AMP molecules (the yellow bodies in the center), the CRP is believed to change its structure so that the two subunits (colored purple on left and green on right) become symmetrical (identical in shape). This the "on" state of the CRP that can bind a gene (DNA) and activate it to carry out functions necessary for the microbe's survival.

Credit

Travis Gallagher, NIST

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.