New research out of VCU Massey Comprehensive Cancer Center—published in Brain, Behavior and Immunity—is the first to suggest that a tumor-driving gene known as AEG-1 actively regulates the inflammation responsible for causing chemotherapy-induced peripheral neuropathy (CIPN), a common and painful side effect of cancer treatment. Eliminating the function of this gene using targeted therapies could become a critical strategy for managing a debilitating side effect experienced by many cancer patients.

CSHL Associate Professors Justin Kinney and David McCandlish have developed a unified theory for mathematical parameters known as gauge freedoms. Their new formulas will allow scientists to interpret research results much faster and with greater confidence. The development could prove fundamental for future efforts in agriculture, drug discovery, and beyond.