Poor blood sugar control in adolescence increases the risk of neuropathy complications for people with type 1 diabetes, research co-led by University of Michigan suggests. The 30-year study found that participants with the greatest increase in HbA1c levels from childhood to adolescence not only retained higher blood sugar levels in adulthood, but they also had a greater risk for neuropathy. The findings emphasize the importance of supporting teenagers with type 1 diabetes to manage their blood sugar and ensure a smooth transition to adult care.

Despite advancements in treatment and prevention, patients with established atherosclerotic cardiovascular disease (ASCVD) still have particularly high risk of having another heart attack, stroke, or other cardiovascular event. Drawing on data from tens of thousands of patients from two independent sources, investigators from Mass General Brigham developed and validated new tools for quantifying this “residual risk” in patients with prior myocardial infarction, stroke, coronary artery disease, peripheral arterial disease, transient ischemic attack, or arterial revascularization. The novel scoring tools substantially improved risk discrimination compared with the guidelines-recommended model. Their findings are published in The Journal of the American College of Cardiology.

While current multiple sclerosis treatments can reduce inflammation, no therapies yet exist to protect neurons or restore the damaged myelin sheath. Researchers have now taken a major step forward in the development of such a therapy. They have identified two compounds that could remyelinate damaged axons.