A research project funded by NIH has generated one of the most extensive and diverse collections of patient-derived tumor models. Tumor tissue from hundreds of cancer patients contributed to the compendium of tumor models that will enhance the study of tumor biology and be an asset in accelerating the development of cancer therapies while guiding future research directions.

An NIH-funded study indicates that the immune landscape of the hippocampus, a brain region critical for learning and memory, rapidly undergoes substantial remodeling beginning in midlife. This previously unrecognized shift suggests a mechanism by which aging may contribute to neurodegenerative disease.

By inducing specific patterns of activity in small portions of the brain in awake mice, researchers supported by the National Institutes of Health (NIH) have triggered a recalibration of neural connections that normally only occurs during sleep. This new approach offset the effects of sleep deprivation in memory tasks and revealed features of sleep that are key to its restorative effect.

A team of NIH researchers have unveiled new details about the events GLP-1 receptor agonists trigger within neurons, which have been largely unexplored until now. A study in mice identified key intracellular signaling processes that are tied to the weight-loss effects of the GLP-1 drug semaglutide. The findings improve our understanding of how increasingly prevalent GLP-1s may influence human behavior and identify new opportunities to potentially enhance treatment.