Tumor targeting by cRGD-ZW800-PEG in rabbits with lung tumors. (IMAGE)
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Tumor targeting by cRGD-ZW800-PEG in rabbits with lung tumors. A, B. Dose optimization of cRGD-ZW800-PEG (green) for lung tumor targeting in rabbits. C. Top, representative ex vivo lung images of color, 800 nm NIR fluorescence (NIR800), and merged. Bottom, H&E, bright-field, and NIR800 fluorescence images of tumor tissue. The red dotted line indicates tumor margin with the tumor tissue being above the red dotted line and showing NIR 800 nm fluorescence signal. D. Comparison of lung tumor targetability between cRGD-ZW800-PEG and ICG. ****P<0.0001, as determined by one-way ANOVA (n=4, mean±SD). White scale bars=0.5 cm, red scale bars=50 µm. Representative in vivo lung tumor images are shown.
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