KMAP Figure 2 (IMAGE)
Caption
Figure 2: Schematic illustration of enhancer regulation in Ewing sarcoma versus the healthy state. In Ewing sarcoma (top), the transcriptional repressor ETV6 competitively binds to transcription factor FLI1 binding sites and closes the enhancer regions, contributing to disease progression. Upon ETV6 degradation (bottom), the enhancer becomes accessible in the presence of FLI1 alone, allowing other transcription factors—BACH1, OTX2, KCNH2, and a potential unknown TF—to bind. These factors often co-localize within a window of about 70 base pairs near the motif CCCAGGCTGGAGTGC and may function jointly in regulating gene expression.
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Lu Cheng
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