Enhancer landscapes in spinal cord tissues of rats with NP. (IMAGE)
Caption
(A) Experimental validation of NP rat model by detecting PWT and NSF. (B) The expression levels of IL-6, TNF-α, and IL-1β were detected by ELISA in respective groups. (C) The counts of peak length by H3K27ac-based chromatin immunoprecipitation sequencing were calculated in both groups. (D) The landscape of the H3K27ac enrichment profile surrounding the transcription start site in SNI-NP and sham rat tissues. (E) The abundance of reads surrounding TSS and TES was calculated in SNI and sham rats. (F) Calculation and distribution of H3K27ac enriched reads in genome area. (G) Genomic distribution of differentially enriched peaks between SNI-NP and sham rats. The statistical results were presented as mean ± standard deviation. Student's t-test was used to determine the significance of the difference between the two groups. The asterisks indicate significance values (∗∗∗P < 0.001). NP, neuropathic pain; PWT, paw-withdrawal threshold; NSF, the number of spontaneous flinches; SNI, spared nerve injury; ELISA, enzyme‐linked immunosorbent assay; TSS, transcription start site; TES, transcription end sites.
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Genes & Diseases
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