Jmjd1c inhibits NP progression via promoting H3K9 demethylation at the Socs3 promoter region. (IMAGE)
Caption
(A) Chromatin immunoprecipitation analysis revealed that the enriched level of Jmjd1c in the promoters Socs3 was significantly lower in SNI-NP rat tissues than those of sham rats. (B) Chromatin immunoprecipitation analysis showed that the enriched level of Jmjd1c at the Socs3 promoter region was significantly higher in Jmjd1c-overexpressing rats. (C) Chromatin immunoprecipitation analysis indicated the enriched level of H3K9me1 at the Socs3 promoter region was significantly lower in Jmjd1c-overexpressing rats. (D) Western blotting analysis showed the Jmjd1c suppressed the phosphorylation levels of JAK2 and STAT3. (E) The schematic model for the mechanisms of Jmjd1c in NP progression. The statistical results were presented as mean ± standard deviation. Student's t-test was used to compare the means from two different data sets. The asterisks indicate significance values (∗∗∗P < 0.001). NP, neuropathic pain.
Credit
Genes & Diseases
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND