A new class of molecules against cancer cells refractory to standard treatments (IMAGE)

CNRS

A new class of molecules against cancer cells refractory to standard treatments

Caption

Ferroptosis diagram. Iron is internalized in the cell via the protein CD44 present on its surface, allowing it to acquire metastatic properties and tolerance to standard treatments through epigenetic reprogramming, which plays a key role in cell adaptation. The activation of lysosomal iron by a phospholipid degrader causes the oxidation and rupture of cell membranes, leading to cell death.

Credit

@ Raphaël Rodriguez

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