Comparative Effects of PAF on Smooth Muscles in Different Regions of the Rat Gastrointestinal Tract (IMAGE)
Caption
This figure shows how a substance called PAF (platelet-activating factor) affects the muscles in different parts of the digestive tract in rats. Panels A–F show the muscle movements in six regions: the esophagus (A), upper stomach (B, gastric fundus), duodenum–jejunum (C), ileum (D), ascending colon (E), and descending colon (F). These muscles normally help move food through the digestive system. When PAF was applied, it caused strong contractions and increased tension, especially in the muscles of the esophagus (A) and upper stomach (B). These effects were weaker or more varied in the lower parts of the digestive tract. However, it still caused unusual, rhythmic muscle movements in the ascending colon (E). This experiment suggests that PAF can trigger abnormal movements or spasms in certain digestive organs, and this may help scientists better understand digestive disorders where such symptoms occur.
Credit
Keisuke Obara
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