Bcl6 deficiency in Treg cells results in delayed malignant transformation in the 4NQO-induced HNSCC model. (IMAGE)
Caption
(A) The schematic diagram of the 4NQO-induced HNSCC model. Drinking water containing 4NQO was administrated to KO mice (n = 13) and WT mice (n = 12) weekly for consecutive 16 weeks and then changed to regular water until the endpoint of week 24. (B) Weight loss was calculated by the body weight at week 16 subtracted from that at week 24. (C) Representative images of the tongues in different groups. Red arrows indicate the white lesions. (D) Representative hematoxylin and eosin staining of the tongue lesions. (E) The histological proportion of tongue lesions. Data were presented as mean ± standard error of the mean calculated by unpaired t-tests for (B, C) and the Kruskal–Wallis test for (E); n ≥ 12; data are representative of at least three independent experiments; ∗∗P < 0.01.
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Genes & Diseases
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