Transcriptional profiles of Treg cells in draining lymph nodes. (IMAGE)
Caption
(A) Volcano plots for the differentially expressed genes (DEGs) of KO Treg cells versus WT Treg cells. Red and blue dots denote up-regulated and down-regulated DEGs, respectively, with |log2 fold change| > 0.5 and false discovery rate <0.05. (B) Heatmap of selected genes in KO Treg cells and WT Treg cells. (C) Gene ontology (GO) pathway analysis of DEGs. Red and blue stripes denote enriched pathways in KO Treg cells and WT Treg cells, respectively. (D) Quantitative reverse transcription PCR analysis of the transcription levels of the indicated genes, normalized to their expression in KO Treg cells. (E,F) Expression level of H3K4me1 and H3K4m3 in dLN Treg cells. dLNs, draining lymph nodes. Data were presented as mean ± standard error of the mean and calculated by unpaired t-test; n ≥ 3; ∗P < 0.05, ∗∗P < 0.01.
Credit
Genes & Diseases
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