Model for G4 suppression (IMAGE)
Caption
Cells use a step-by-step process to untie knots in DNA, called G4 structures. First, the G4 knot is recognized as a problem by the cell. Special DNA damage response proteins start the repair by recruiting DNA repair proteins, which help form a loop with RNA, called a G-loop. Next, other DNA repair proteins like FANCJ untie the G4 knot and cut the loop. Finally, the cell repairs the DNA to keep it healthy. This protects the genome and prevents damage that could harm the cell.
Credit
Credit: Koichi Sato and Puck Knipscheer, Copyright: Hubrecht Institute
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