Photoacoustic stimulation of neurons in mPFC alleviates SDS-induced anxiety and social dysfunction. (IMAGE)
Caption
Fig. 3 | Photoacoustic stimulation of neurons in mPFC alleviates SDS-induced anxiety and social dysfunction. (a) Time line of the experimental procedure. Mice were implanted with a FPE. After 3 days, the mice underwent OFT and 3-chamber test to assess baseline behavior. Following a 1-hour SDS session, the anxiety was re-evaluated in the OFT and 3-chamber test. Subsequently, mice received either photoacoustic stimulation or sham stimulation for 1 hour before undergoing another OFT and 3-chamber test. (b) Diagram of the OFT setup and the central zone. (c) The total distance traveled and the time spent in the center zone of the OFT arena. (d) Representative trajectory plots from the OFT. (e) Diagram of the 3-chamber test. The diagrams represent session 1 and session 2. (f) Statistical analysis of the percentage of time spent with the left mouse in session 1 and the percentage of time spent with the right mouse in session 2. (g) Heatmaps of mouse movement trajectories. *p<0.05, **p<0.01.
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Jiapu Li, Xinghua Liu, Zhuohua Xiao, Zhengying Li, Xinghua Liu
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