STARD4 knockdown suppresses tumorigenesis and enhances the anti-tumor effect of lenvatinib in vivo. (IMAGE)
Caption
(A) The images of xenografts in the ffour groups with different treatments. (B) Effect of STARD4 knockdown, lenvatinib, and combination of STARD4 knockdown with lenvatinib on the tumor volume of the nude mice. (C) The body weight of the nude mice in each group was weighed daily and shown. (D) Effect of STARD4 knockdown, lenvatinib, and combination of STARD4 knockdown with lenvatinib on the tumor weight of the nude mice. (E) Immunohistochemical analysis indicated the protein abundance of STARD4, p-EGFR, p-PI3K, and p-AKT in the tumor tissues obtained from the nude mice in different groups. The data were shown as mean ± standard deviation (n = 6). *P < 0.05, **P < 0.01, and ***P < 0.001 versus the corresponding control.
Credit
Mengting Liu, Yixin Liu, Jiahui Zheng, Xiangping An, Jiayong Wen, Fengchi Zhu, Jin Jia, Dan Guo, Nana Chen
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