Single-cell RNA sequencing (scRNA-seq) identified four clusters of human embryonic eye lens cell clusters. (IMAGE)
Caption
(A) Schematic diagram of the human embryonic eyes design. (B) The uniform manifold approximation and projection (UMAP) algorithm was used to group the fetal lens scRNA-seq data into four clusters, each representing a unique combination of cell type and age. (C) UMAP embedding of the fetal lens scRNA-seq dataset, with individual cells colored by cell cycle. (D) The distribution of cell cycles in each cluster. (E) Within each fetal lens cluster, the top 10 most significant differences were observed in four distinct groups, namely lens fiber cells (FiberCell), transitional cells (TransitionalCell), lens epithelial cells (EpithelialCell), and unknown cluster (Others). (F) Marker gene expression distribution in lens epithelial cells and lens fiber cells.
Credit
Huiping Lu, Xianyang Liu, Qian Zhou, Ruonan Li, Hangjia Zuo, Ke Hu, Meng Tian, Hong Wang, JianqiaoLi, Na Li, Shengping Hou
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